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首页> 外文期刊>Alcohol >Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli
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Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli

机译：大鼠菌株及诱导乙醇饮用方法对帕夫洛韦 - 工具转移的影响，用乙醇配对调理刺激

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Ethanol-paired conditioned stimuli (CSs) are widely thought to invigorate ethanol responding, and thus, precipitate relapse to drinking. However, preclinical studies investigating this issue using Pavlovian-Instrumental-Transfer (PIT) procedures have had mixed results, with some studies finding PIT while others did not. The studies failing to show PIT used Lewis rats and induced ethanol drinking using a post-prandial drinking procedure. The present experiments examined whether either of these two variables influenced the magnitude of PIT observed. In the first experiment, ethanol drinking in Lewis rats was induced using either sucrose fading or post-prandial drinking. In the second experiment, ethanol drinking was induced using post-prandial drinking in either Long-Evans Hooded or Lewis rats. In both experiments, rats were trained to respond for ethanol under a random interval schedule. Subsequently with the lever removed, 2-min light presentations were paired with ethanol deliveries. Finally, with the lever returned, the effect of light presentations on responding was tested while responding was in extinction. Light presentations similarly affected responding in Lewis rats regardless of the method of drinking induction. Likewise, light presentations similarly affected responding in both Lewis and Long-Evans Hooded rats. Neither ethanol induction method nor rat strain affected the magnitude of PIT observed, and thus, neither likely explains previous failures to observe PIT with ethanol-maintained behavior. (C) 2019 Elsevier Inc. All rights reserved.
机译：乙醇配对条件刺激（CSS）被广泛认为激活乙醇应对，因此沉淀到饮酒中的复发。然而，研究使用Pavlovian-Ornager-Transfer（PIT）程序调查这个问题的临床研究已经发生了混合的结果，其中一些研究发现坑，而其他研究则没有。未能展示坑的研究使用路易斯大鼠并使用折叠后饮用程序诱导乙醇饮用。本实验检查了这两个变量中的任何一种是否影响了观察到的坑的大小。在第一次实验中，使用蔗糖衰落或伪装后饮用诱导Lewis大鼠乙醇饮用。在第二种实验中，使用长埃文斯连帽或路易斯大鼠的折补后饮用诱导乙醇饮用。在两个实验中，培训大鼠以在随机间隔时间表中培训以对乙醇进行响应。随后与杠杆移除，将2分钟的光呈递与乙醇递送配对。最后，随着杠杆返回，在响应灭绝时测试了光线呈现对响应的影响。无论饮用诱导方法如何，Light Chinksies在Lewis大鼠中相似受到影响。同样，轻型演示在刘易斯和长埃文斯连帽大鼠中同样受到影响。乙醇诱导方法和大鼠应变都不会影响观察到的坑的大小，因此，两者都不解释以前观察到乙醇保持行为的坑。 （c）2019 Elsevier Inc.保留所有权利。

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