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首页> 外文期刊>Alcohol >Prevention of alcohol-induced DNA damage by a proprietary glycyrrhizin/D-mannitol product: A randomized, placebo-controlled, cross-over human study
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Prevention of alcohol-induced DNA damage by a proprietary glycyrrhizin/D-mannitol product: A randomized, placebo-controlled, cross-over human study

机译：通过专有的甘草蛋白/ D-甘露醇产品预防酒精诱导的DNA损伤：随机，安慰剂控制，交叉人类研究

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ObjectivesThe purpose of the present study was to evaluate the ability of a proprietary combination of glycyrrhizin and D-mannitol to protect against oxidative damage to DNA associated with acute alcohol consumption by human subjects in a randomized, placebo-controlled cross-over designed study. Excessive alcohol consumption is associated with numerous diseases. Alcohol has been shown to generate reactive oxygen species that can result in DNA damage, leading to genetic and epigenetic changes. MethodsA total of 25 subjects (13 male and 12 female) were enrolled. Alcohol intake in the form of vodka (40% ethanol) was adjusted based on 1.275?g of 100% ethanol/kg body weight for men and 1.020?g/kg body weight for women, which was consumed with and without the study product. Blood samples were drawn at 2?h after alcohol consumption, lymphocytes were isolated, and were subjected to DNA comet electrophoresis on a blinded basis. ResultsAcute alcohol consumption increased lymphocyte DNA damage by approximately 8.36%. Co-consumption of the glycyrrhizin/D-mannitol study product with alcohol reduced DNA damage to baseline levels. No adverse effects were associated with use of the study product, and no differences were observed in blood alcohol concentrations in the presence or absence of the study product in males and females. ConclusionsAcute alcohol ingestion resulted in measurable increases in DNA damage, which were prevented by the addition of the proprietary glycyrrhizin/D-mannitol (NTX?) study product to the alcohol, suggesting that the tissue-damaging effects of alcohol consumption can be ameliorated.
机译：本研究的客观目的是评估甘草蛋白和D-甘露醇的专有组合对随机安慰剂控制的交叉设计研究中的人类受试者对急性醇消耗相关的氧化损伤的能力。过量的酒精消费与许多疾病有关。已显示醇产生可导致DNA损伤的反应性氧物种，导致遗传和表观遗传变化。 Methablea共有25项受试者（13名男性和12名女性）。基于1.275克（40％乙醇）的醇摄入量的vodka（40％乙醇），适用于男性的1.275克/ kg体重和1.020？g / kg体重的女性，其中包括和没有研究产品。在醇消耗后在2℃下拉出血液样品，分离淋巴细胞，并在致盲的基础上进行DNA彗星电泳。结果醇消耗增加淋巴细胞DNA损伤约8.36％。甘草蛋白/ D-甘露醇研究产品的共消耗用酒精降低DNA损伤基线水平。没有对研究产物的使用无副作用，并且在血液和女性中的研究产品存在或不存在中，在血液醇浓度中没有观察到差异。结论DNA损伤导致DNA损伤导致的可测量增加，通过添加专有的甘草蛋白/ D-甘露醇（NTXα）研究产物对酒精进行了可测量的，这表明可以改善醇消耗的组织损伤效应。

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