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首页> 外文期刊>Alcohol >Alcohol-na?ve USVs distinguish male HAD-1 from LAD-1 rat strains
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Alcohol-na?ve USVs distinguish male HAD-1 from LAD-1 rat strains

机译：酒精-NA？VE USVs与Lad-1大鼠菌株区分雄性患有-1

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Ultrasonic vocalizations (USVs) are mediated through specific dopaminergic and cholinergic neural pathways and serve as real-time measures of positive and negative emotional status in rodents. Although most USV studies focus primarily on USV counts, each USV possesses a number of characteristics shown to reflect activity in the associated neurotransmitter system. In the present study, we recorded spontaneously emitted USVs from alcohol-na?ve high alcohol drinking (HAD-1) and low alcohol drinking (LAD-1) rats. Using our recently developed WAAVES algorithm, we quantified four acoustic characteristics (mean frequency, duration, power, and bandwidth) from each 22–28?kHz and 50–55?kHz frequency-modulated (FM) USV. This rich USV representation allowed us to apply advanced statistical techniques to identify the USV acoustic characteristics that distinguished HAD-1 from LAD-1 rats. Linear mixed models (LMM) examined the predictability of each USV characteristic in isolation and linear discriminant analysis (LDA), and binomial logistic regression examined the predictability of linear combinations of the USV characteristics as a group. Results revealed significant differences in acoustic characteristics between HAD-1 and LAD-1 rats in both 22–28?kHz and 50–55?kHz FM USVs. In other words, these rats selectively bred for high- and low-alcohol consumption can be identified as HAD-1 or LAD-1 rats with high classification accuracy (approximately 92–100%) exclusively based on their emitted 22–28?kHz and 50–55?kHz FM USV acoustic characteristics. In addition, acoustic characteristics of 22–28?kHz and 50–55?kHz FM USVs emitted by alcohol-na?ve HAD-1 and LAD-1 rats significantly correlate with their future alcohol consumption. Our current findings provide novel evidence that USV acoustic characteristics can be used to discriminate between alcohol-na?ve HAD-1 and LAD-1 rats, and may serve as biomarkers in rodents with a predisposition for, or against, excessive alcohol intake.
机译：超声波发作（USV）通过特异性多巴胺能和胆碱能神经途径介导，并用作啮齿动物中的正面和负面情绪状态的实时测量。尽管大多数USV研究主要关注USV计数，但每个USV都具有许多特征，显示出在相关的神经递质系统中反映活动。在本研究中，我们从酒精-NA ve高级酒精（HAD-1）和低级酒精（LAD-1）大鼠中录制了自发发出的USV。使用我们最近开发的Waves算法，我们量化了来自每22-28 kHz和50-55 kHz和50-55 kHz的四个声学特性（均值，持续时间，功率和带宽），频率调制（FM）USV。这种富裕的USV代表允许我们应用高级统计技术，以识别从Lad-1大鼠的患有-1的USV声学特性。线性混合模型（LMM）检查了分离和线性判别分析（LDA）中每个USV特征的可预测性，并且二项式逻辑回归检查了USV特征作为组的线性组合的可预测性。结果表明，在22-28 kHz和50-55岁以下的HAD-1和LAD-1大鼠之间的声学​​特性差异显着差异。换句话说，可选择性地培育的这些大鼠用于高醇消耗量，可识别为具有高分类精度（约92-100％）的HAT-1或Lad-1大鼠，该大鼠专门基于其发射的22-28 kHz和50-55？KHz FM USV声学特性。此外，由酒精-NA'VEAT-1和LAD-1大鼠发出的22-28 kHz和50-55的声学特性和50-55？KHz FM USV与他们未来的饮酒显着相关。我们目前的调查结果提供了一种新颖的证据，即USV声学特性可用于区分酒精-Nαve和Lad-1大鼠，并且可以作为啮齿动物的生物标志物，其具有易感性，或反对过量的酒精摄入量。

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