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首页> 外文期刊>Alcohol >Enhanced sensitivity to socially facilitating and anxiolytic effects of ethanol in adolescent Sprague Dawley rats following acute prenatal ethanol exposure
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Enhanced sensitivity to socially facilitating and anxiolytic effects of ethanol in adolescent Sprague Dawley rats following acute prenatal ethanol exposure

机译：在急性产前乙醇暴露之后，增强了对青少年Sprague Dawley大鼠乙醇的社会促进和抗焦虑作用的敏感性

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Emerging evidence suggests that deficits in social functioning and social anxiety are associated with adolescent alcohol use. Our previous research has shown that acute exposure to a high dose of ethanol on gestational day (G) 12 produces social alterations in adolescent Sprague Dawley rats. The present study assessed whether these social alterations can affect sensitivity to acute ethanol challenge during adolescence. Pregnant females were exposed intraperitoneally (i.p.) to ethanol (2.5?g/kg followed by 1.25?g/kg in 2?h) or saline on G12, and their male and female offspring were tested on postnatal day (P) 42. Rats were challenged i.p. with one of four ethanol doses (0, 0.5, 0.75, and 1.0?g/kg), and their social behavior was assessed in a modified social interaction test. Social alterations associated with prenatal ethanol exposure and indexed via decreases of social investigation, social preference, and play fighting were evident in males and females challenged with the 0?g/kg ethanol dose. Acute ethanol increased social investigation, social preference, and play fighting in animals prenatally exposed to ethanol. In contrast, rats prenatally exposed to saline, showing no social facilitation, demonstrated significant ethanol-induced (0.75 and 1.0?g/kg) decreases in social behavior. Given that late adolescents demonstrating social alterations induced by prenatal ethanol exposure become sensitive to the socially anxiolytic as well as socially facilitating effects of acute ethanol, it is possible that the attractiveness of ethanol to these adolescents may be based on its ability to alleviate anxiety under social circumstances and facilitate interactions with peers.
机译：新兴的证据表明，社会功能和社会焦虑的赤字与青少年酒精使用有关。我们以前的研究表明，急性暴露于妊娠期（G）12的高剂量乙醇中产生了青少年Sprague Dawley大鼠的社会改变。本研究评估了这些社会改变是否会影响青春期期间对急性乙醇攻击的敏感性。怀孕的女性将腹膜内（IP）暴露于乙醇（2.5？G / kg，然后在2℃）或在2·H）或G12上的盐水，并在后期（P）42上测试它们的雄性和雌性后代。大鼠受到挑战的IP.用四种乙醇剂量（0,0.5,0.75和1.0？G / kg）中的一种，并在改进的社交互动测试中评估其社会行为。通过减少社会调查，社会偏好和竞争的孕产阶级乙醇暴露和指责的社会改变，在麦利和女性中，挑战0？G / kg乙醇剂量。急性乙醇增加社会调查，社会偏好，并在暴露于乙醇的动物中的运动。相反，预先暴露于盐水的大鼠，显示没有社会促进，证明了社会行为下降的显着乙醇诱导的（0.75和1.0？G / kg）。鉴于普通乙醇暴露诱导的晚期青少年对社会抗氧性以及急性乙醇的社会促进作用变得敏感，乙醇对这些青少年的吸引力可能是基于其缓解社会焦虑的能力情况，促进与同龄人的互动。

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