...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS >The undiagnosed HIV epidemic in France and its implications for HIV screening strategies
【24h】

The undiagnosed HIV epidemic in France and its implications for HIV screening strategies

机译：法国未确诊的艾滋病毒疫情及其对HIV筛查策略的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND:: Describing the undiagnosed HIV-infected population is essential for guiding HIV screening policy, implementing interventions, and resource planning. METHODS:: We used French national HIV surveillance data and a back-calculation approach to estimate the number of undiagnosed HIV-infected individuals in France and the distribution of time since HIV infection among undiagnosed individuals. We also used data on CD4 cell count decline to assess the CD4 cell count distribution among undiagnosed individuals. RESULTS:: We estimated that 29000 [95% confidence interval (CI): 24200-33900] individuals were living with undiagnosed HIV infection at the end of 2010. Of these, 28.7% (95% CI: 27.1-30.4) were infected less than a year ago, 16.4% (95% CI: 15.0-17.8) more than 5 years ago, and 59.6% (95% CI: 59.2-59.8) were eligible for antiretroviral treatment (CD4 cell count less than 500 cells/μl) according to the 2010 French guidelines. Men represented 70.0% of the undiagnosed HIV-infected individuals and had lower CD4 cell counts than women. The numbers of undiagnosed infections in MSM, non-French national heterosexuals, and French national heterosexuals were similar (9200, 9300, 10000, respectively). However, because of differences in group size, undiagnosed HIV prevalence varied significantly between these groups (2.95, 0.36, 0.03%, respectively; P less than 0.001). CONCLUSION:: Our findings suggest that many undiagnosed HIV-infected individuals were eligible for treatment and, thus, lack of HIV diagnosis is a lost chance for them; many more heterosexuals than MSM will need to be tested to find those undiagnosed; and universal screening of men may be cost-effective, especially in the areas most affected by the epidemic, such as the Paris region.
机译：背景：描述未确诊的艾滋病毒感染的人口对于指导艾滋病毒筛查政策，实施干预措施和资源规划至关重要。方法::我们使用法国国家艾滋病毒监测数据和背部计算方法来估算法国未确诊的艾滋病毒感染的个体数量和未确诊个人中艾滋病毒感染以来的时间分配。我们还使用CD4细胞计数下降的数据，以评估未诊断的个体中的CD4细胞计数分布。结果::我们估计，29000 [95％的置信区间（CI）：24200-33900]个人在2010年底患有未诊断的HIV感染。其中，28.7％（95％CI：27.1-30.4）感染了较少超过一年前，5年前16.4％（95％CI：15.0-17.8），59.6％（95％CI：59.2-59.8）符合抗逆转录病毒治疗（CD4细胞计数小于500个细胞/μl）根据2010年法国指南。男性代表未经治疗的艾滋病毒感染的个体的70.0％，并且比女性低CD4细胞计数。 MSM，非法国民族异性恋和法国民族异性恋的未确诊感染的数量相似（分别为9200,9300,10000）。然而，由于群体大小的差异，未确诊的艾滋病毒患病率在这些组之间有显着变化（2.95,0.36,0.03％; P小于0.001）。结论::我们的研究结果表明，许多未诊断的艾滋病毒感染的个体有资格进行治疗，因此，缺乏艾滋病病毒诊断是对他们失去的机会;需要测试更多的异性恋者，以发现未确诊的异性恋;普遍筛查人类可能是具有成本效益，特别是在受到疫情受影响的区域，例如巴黎地区。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号