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首页> 外文期刊>Acta neurobiologiae experimentalis >Molecular basis of dendritic arborization.
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Molecular basis of dendritic arborization.

机译:树突状乔木化的分子基础。

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摘要

The pattern of dendritic branching along with the receptor and channel composition and density of synapses regulate the electrical properties of neurons. Abnormalities in dendritic tree development lead to serious dysfunction of neuronal circuits and, consequently, the whole nervous system. Not surprisingly, the complicated and multi-step process of dendritic arbor development is highly regulated and controlled at every stage by both extrinsic signals and intrinsic molecular mechanisms. In this review, we analyze the molecular mechanisms that contribute to cellular processes that are crucial for the proper formation and stability of dendritic arbors, in such distant organisms as insects (e.g. Drosophila melanogaster) amphibians (Xenopus laevis) and mammals.
机译:树突分支的模式与受体和通道的组成以及突触的密度一起调节神经元的电特性。树状树发育异常会导致神经元回路严重功能障碍,进而导致整个神经系统功能异常。毫不奇怪,树突状乔木发育的复杂且多步骤的过程在每个阶段都受到外部信号和内在分子机制的高度调控。在这篇综述中,我们分析了在昆虫(例如果蝇果蝇)两栖动物(非洲爪蟾)和哺乳动物等远距离生物中对树突状树突的正确形成和稳定性至关重要的细胞过程的分子机制。

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