Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking.

N C Thomson; R Chaudhuri; M Spears; C M Messow; S Jelinsky; G Miele; K Nocka; E Takahashi; O J Hilmi; M C Shepherd; D K Miller; C McSharry

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Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking.

机译：哮喘中的花生素酸代谢物和酶转录物被吸烟改变。

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Several arachidonic acid metabolites and enzyme transcripts involving both lipoxygenase and cyclooxygenase pathways are increased in smokers with asthma and differ from never smokers with asthma. Possibly targeting specific lipoxygenase and cyclooxygenase pathways that are activated by asthma and cigarette smoking may optimize therapeutic responses.

机译：涉及脂氧合酶和环氧化酶途径的几种花生酸代谢物和酶转录物在吸烟者中增加了哮喘的吸烟者，与哮喘的吸烟者不同。可能靶向由哮喘和香烟吸烟激活的特异性脂氧合酶和环加氧酶途径可以优化治疗性反应。

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来源
《Allergy》 |2014年第4期|共10页
作者
N C Thomson; R Chaudhuri; M Spears; C M Messow; S Jelinsky; G Miele; K Nocka; E Takahashi; O J Hilmi; M C Shepherd; D K Miller; C McSharry;
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作者单位

Institute of Infection Immunity &

Inflammation University of Glasgow Glasgow UK;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
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1. Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. [J] . N C Thomson, R Chaudhuri, M Spears, Allergy . 2014,第4期

机译：吸烟会改变哮喘中的花生四烯酸代谢产物和酶转录物。
2. Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids [J] . Otoki Yurika, Metherel Adam H., Pedersen Theresa, Lipids . 2020,第1期

机译：急性高腺癌/缺血改变了大鼠脑中性脂质的酸辛酸和二十二碳己酸环氧化物代谢物的酯化
3. Effects of fluticasone propionate on arachidonic acid metabolites in BAL-fluid and methacholine dose-response curves in non-smoking atopic asthmatics [J] . S. E.Overbeek, J. M.Bogaard, I. M.Garrelds, Mediators of inflammation . 1996,第3期

机译：丙酸氟替卡松对非吸烟性特应性哮喘患者BAL液中花生四烯酸代谢产物和乙酰甲胆碱剂量反应曲线的影响
4. Formation of 11-Oxo-Eicosatetraenoic Acid, a Novel Cyclooxygenase-2- and 15-Hydroxyprostaglandin Dehydrogenase-Derived Arachidonic Acid Metabolite [C] . Cong Wei, Suhong Zhang, Xiaojing Liu, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：形成11-氧代己二辛酸，新型环氧氧酶-2-和15-羟化淀粉蛋白脱氢酶衍生的花生酸代谢物
5. Mechanisms by Which Arachidonic acid Metabolite, Epoxyeicosatrienoic acid Elicit Cardioprotection Against Ischemic Reperfusion Injury. [D] . Batchu, Sri Nagarjun. 2011

机译：花生四烯酸代谢产物，环氧二十碳三烯酸诱导抗缺血再灌注损伤的心脏保护机制。
6. In vitro release of arachidonic acid metabolites, glutathione peroxidase, and oxygen-free radicals from platelets of asthmatic patients with and without aspirin intolerance. [O] . V. Plaza, J. Prat, J. Rosellò, 2018

机译：患有和没有阿司匹林耐受性的哮喘患者血小板中花生四烯酸代谢产物，谷胱甘肽过氧化物酶和氧自由基的体外释放。
7. Altered Release of Cytochrome P450 Metabolites of Arachidonic Acid in Renovascular Disease [O] . Paola Patrignani, Alberto Morganti, Ro Lechi, 2015

机译：改变释放花生病中花生四烯酸的细胞色素p450代谢物

Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking.

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