...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >CD14 polymorphisms, microbial exposure and allergic diseases: A systematic review of gene-environment interactions
【24h】

CD14 polymorphisms, microbial exposure and allergic diseases: A systematic review of gene-environment interactions

机译：CD14多态性，微生物暴露和过敏性疾病：对基因环境相互作用的系统综述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Asthma and allergy may develop as a result of interactions between environmental factors and the genetic characteristics of an individual. This review aims to summarize the available evidence for, and potential effects of, an interaction between polymorphisms of the CD14 gene and exposure to microbes on the risk of asthma and allergic diseases. We searched PubMed, MEDLINE and Global Health databases, finding 12 articles which met inclusion criteria. Most studies reported a significant interaction between CD14 polymorphisms and microbial exposure. When stratified by age at microbial exposure (early life vs adult life), there was evidence of a protective effect of gene-environment interaction against atopy in children, but not adults. We also found different effects of interaction depending on the type of microbial exposures. There was no strong evidence for asthma and eczema. Future studies should consider a three-way interaction between CD14 gene polymorphisms, microbial exposures and the age of exposure.
机译：由于环境因素与个人遗传特征之间的相互作用，哮喘和过敏可能会发生。该审查旨在总结CD14基因多态性与微生物对哮喘和过敏性疾病的风险的多态性之间的可用证据和潜在影响。我们搜索了PubMed，Medline和全球健康数据库，找到了12篇符合纳入标准的文章。大多数研究报告了CD14多态性与微生物暴露之间的显着相互作用。当按年龄在微生物暴露（早期寿命vs成年人的年龄）分层时，有证据表明基因 - 环境相互作用对儿童的特性，但不是成年人。我们还根据微生物曝光的类型发现相互作用的不同效果。哮喘和湿疹没有强有力的证据。未来的研究应考虑CD14基因多态性，微生物暴露和暴露年龄之间的三元相互作用。

著录项

  • 来源
    《Allergy》 |2014年第11期|共14页
  • 作者

    LauM.Y.Z.; DharmageS.C.; BurgessJ.A.; LoweA.J.; LodgeC.J.; CampbellB.; MathesonM.C.;

  • 作者单位

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

    Centre for Epidemiology and Biostatistics School of Population and Global Health University of;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    asthma; atopy; CD14; endotoxin; gene-environment interaction;

    机译：哮喘;特性;CD14;内毒素;基因环境相互作用;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号