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CD14 polymorphisms, microbial exposure and allergic diseases: A systematic review of gene-environment interactions

机译：CD14基因多态性，微生物暴露和过敏性疾病：基因-环境相互作用的系统评价

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Asthma and allergy may develop as a result of interactions between environmental factors and the genetic characteristics of an individual. This review aims to summarize the available evidence for, and potential effects of, an interaction between polymorphisms of the CD14 gene and exposure to microbes on the risk of asthma and allergic diseases. We searched PubMed, MEDLINE and Global Health databases, finding 12 articles which met inclusion criteria. Most studies reported a significant interaction between CD14 polymorphisms and microbial exposure. When stratified by age at microbial exposure (early life vs adult life), there was evidence of a protective effect of gene-environment interaction against atopy in children, but not adults. We also found different effects of interaction depending on the type of microbial exposures. There was no strong evidence for asthma and eczema. Future studies should consider a three-way interaction between CD14 gene polymorphisms, microbial exposures and the age of exposure.
机译：环境因素与个体遗传特征之间相互作用会导致哮喘和过敏。这篇综述旨在总结CD14基因多态性与暴露于微生物之间的相互作用对哮喘和过敏性疾病风险的可用证据及其潜在影响。我们搜索了PubMed，MEDLINE和Global Health数据库，找到了符合纳入标准的12篇文章。大多数研究报告了CD14多态性与微生物暴露之间的显着相互作用。当按暴露于微生物的年龄（早年与成年生活）进行分层时，有证据表明基因-环境相互作用对儿童而非成年人的特应性有保护作用。我们还发现了相互作用的不同影响，具体取决于微生物暴露的类型。没有强有力的证据表明哮喘和湿疹。未来的研究应考虑CD14基因多态性，微生物暴露与暴露年龄之间的三向相互作用。

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