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首页> 外文期刊>Allergy >Higher mortality of adults with asthma: A 15‐year follow‐up of a population‐based cohort
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Higher mortality of adults with asthma: A 15‐year follow‐up of a population‐based cohort

机译：具有哮喘的成年人的死亡率更高：基于人口的队列的15年后续行动

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Abstract Background Higher all‐cause mortality in asthmatics has been shown previously. Polysensitization is associated with higher morbidity among asthmatic children, and allergic rhinitis and/or allergic conjunctivitis ( AR / AC ) are associated with higher morbidity in adult asthmatics. Little is known about the effect of AR / AC and other factors on mortality among adult asthmatics. The aim was to study mortality and its risk factors in adults with and without asthma. Methods We randomly selected 1648 asthmatics with age over 30 years from national registers and matched the asthma sample with one or two controls. Baseline information was obtained by a questionnaire in 1997, and the study population was linked with the death certificate information of Statistics Finland from 1997 to 2013. Overall and cause‐specific survival between the groups was compared in several adjusted models. Results During a mean follow‐up period of 15.6 years, 221 deaths among 1052 asthma patients and 335 deaths among 1889 nonasthmatics were observed. Cardiovascular diseases were the main cause of death in both groups. Asthma was associated with increased all‐cause mortality (adjusted HR 1.25; 95% CI 1.05‐1.49, P = .011) as well as mortality from chronic obstructive pulmonary disease ( HR 12.0, 4.18‐34.2, P .001) and malignant neoplasms of respiratory organs ( HR 2.33, 1.25‐4.42, P = .008). Among asthmatics, smoking was associated with increased all‐cause mortality, and self‐reported AR / AC was associated with decreased mortality. Among nonasthmatics, smoking, and obesity were associated with increased all‐cause mortality, whereas female gender showed an association with a decreased risk. Conclusions Increased mortality among adult asthmatics was largely explained by the development of COPD , malignant respiratory tract neoplasms, and cardiovascular diseases. Smoking cessation is important for reduction in total mortality in both asthmatic and nonasthmatic adults. AR / AC was associated with decreased mortality only in asthmatics. Thus, studies in other populations of larger size are needed to explore further the nature of this association.
机译：摘要背景显示了哮喘学中的全部导致死亡率更高。聚敏化与哮喘儿童的发病率较高，过敏性鼻炎和/或过敏性结膜炎（AR / AC）与成年哮喘学的发病率较高。关于AR / AR和其他因素对成年哮喘学中死亡率的影响很少。目的是在没有哮喘的情况下研究死亡率及其风险因素。方法采用国家寄存器随机选择1648岁以上超过30年的哮喘，并将哮喘样品与一两次控件相匹配。基线信息由1997年问卷获得，研究人群从1997年到2013年与芬兰统计数据的死亡证明信息相关联。在几个调整的模型中，组中的总体而造成的特定生存率。结果在15.6岁的平均随访期间，1052名哮喘患者中的221例死亡和1889名非原始学之间的335例死亡。心血管疾病是两组死亡的主要原因。哮喘与全因死亡率增加有关（调整后的HR 1.25; 95％CI 1.05-1.49，P = .011）以及来自慢性阻塞性肺病的死亡率（HR 12.0,4.18-34.2，P＆ .001）和呼吸器官的恶性肿瘤（HR 2.33,1.25-4.42，P = .008）。在哮喘学中，吸烟与增加的全因死亡率有关，并且自我报告的AR / AC与死亡率降低有关。在非活泼，吸烟和肥胖中与增加的全因死亡率有关，而女性性别表现出与风险降低的关联。结论通过COPD，恶性呼吸道瘤和心血管疾病的发展，大大解释了成年哮喘的死亡率增加。吸烟停止对于哮喘和非发育成年人的总死亡率降低是重要的。 AR / Ac仅在哮喘学中的死亡率降低有关。因此，需要在其他群体的研究进一步探索这种关联的性质。

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