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首页> 外文期刊>Allergy >Associations of Th2, Th17, Treg cells, and IgA + + memory B cells with atopic disease in children: The Generation R Study
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Associations of Th2, Th17, Treg cells, and IgA + + memory B cells with atopic disease in children: The Generation R Study

机译：TH2，TH17，THREG细胞和IGA + + + +血管B细胞与儿童特应疾病的关联：生成R研究

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Abstract Background New insights into immune cells could contribute to treatment and monitoring of atopic disease. Because nongenetic factors shape the human immune system, we here studied these immune cells in a large cohort with atopic children with adjustment for prenatal and postnatal confounders. Methods Information on atopic dermatitis, inhalant‐ and food‐allergic sensitization, asthma lung function scores was obtained from 855 10‐year‐old children within the Generation R cohort. 11‐color flow cytometry was performed to determine CD27 + and CD27 ? IgG + , IgE + and IgA + memory B cells, Th1, Th2, Th17, and Treg‐memory cells from venous blood. Associations between any atopic disease, the individual atopic diseases, and immune cell numbers were determined. Results Children with any atopic disease had higher Th2, Treg, Treg‐memory, and CD27 + IgA + memory B‐cell numbers compared to children without atopic disease. When studying the individual diseases compared to children without the individual diseases, children with atopic dermatitis, inhalant‐, and food‐allergic sensitization had higher memory Treg cell numbers 12.3% (95% CI 4.2; 21.0), (11.1% (95% CI 3.0; 19.8), (23.7% (95% CI 7.9; 41.8), respectively. Children with food‐allergic sensitization had higher total B and CD27 + IgA + memory B‐cell numbers (15.2% [95% CI 3.2; 28.7], 22.5% [95% CI 3.9; 44.3], respectively). No associations were observed between asthma and B‐ or T‐cell numbers. Conclusion Children with any atopic disease and children with inhalant‐ and food‐allergic sensitization or atopic dermatitis had higher circulating memory Treg cells, but not higher IgE + B‐cell numbers. The associations of higher Treg and CD27 + IgA + B‐cell numbers in children with food‐allergic sensitization are suggestive of TGF‐β‐mediated compensation for chronic inflammation.
机译：摘要背景，对免疫细胞的新见解可能有助于治疗和监测特应性疾病。因为环境因素塑造了人类免疫系统，我们在这里研究了这些免疫细胞的大队列，其具有特应性儿童，调整产前和产前的混血。方法有关Atopic皮炎，吸气和食物过敏性致敏的信息，哮喘肺功能分数来自855名10岁儿童，r队列中的855名10岁儿童。进行11色流式细胞术以确定CD27 +和CD27吗？ IgG +，IgE +和IgA +存储器B细胞，Th1，Th2，Th17和来自静脉血的Treg-Memory细胞。确定了任何特应性疾病，个体特征性疾病和免疫细胞数之间的关联。结果具有特应性疾病的儿童具有较高的Th2，Treg，Treg-emcreen和Cd27 + IgA +储存B细胞数与没有特方向性疾病的儿童相比。与没有个体疾病的儿童相比，在没有个体疾病的情况下，具有特应性皮炎，吸气剂和食物过敏致敏的儿童具有较高的记忆TREG细胞数12.3％（95％CI 4.2; 21.0），（11.1％（95％CI） 3.0; 19.8），分别为23.7％（95％CI 7.9; 41.8）。具有食物过敏性敏化的儿童具有更高的B和CD27 + IgA +内存B细胞数（15.2％[95％CI 3.2; 28.7] ，分别为22.5％[95％CI 3.9; 44.3]。哮喘和B型或T细胞数不观察到任何关联。结论患有任何特应性疾病和吸气的儿童和食物过敏性敏化或特应性皮炎的儿童更高的循环记忆Treg细胞，但不高的IgE + B细胞数。较高Treg和CD27 + IgA + B细胞数在具有食物过敏性致敏儿童中的缔合，是TGF-β介面的慢性炎症补偿。

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