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首页> 外文期刊>Acta neurobiologiae experimentalis >Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway.
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Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway.

机译：塞来昔布对戊四唑诱发的惊厥的抗惊厥作用：通过NO途径进行调节。

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摘要

This study aimed to examine whether celecoxib influences clonic seizure thresholds through modulation of nitric oxidergic (NO) pathway. The effect of celecoxib (1-5 mg per kg, p.o.) was investigated on clonic seizures induced by pentylenetetrazole (PTZ, 50 and 80 mg per kg, i.p.) in male Swiss mice. The interaction of celecoxib-induced effects with NO pathway was examined using a NO synthase (NOS) inhibitor, N(G)-omega-nitro-L-arginine methyl ester (L-NAME, 20 and 50 mg per kg, i.p.) and a NOS substrate, L-arginine (100 and 200 mg per kg, i.p.). The criteria for the development of seizure activity were the possibility for appearance of generalized clonus and prolongation of latency to the onset of convulsions following administration of 50 and 80 mg per kg of PTZ, respectively. Pretreatment with celecoxib (2.5 and 5 mg per kg) or L-NAME (50 mg per kg) induced anticonvulsant effect on the PTZ-induced clonic seizures. L-arginine at the dose of 200 mg per kg had proconvulsant effect. A sub-effective dose of celecoxib (1 mg per kg) induced an additive anticonvulsant effect when co-administered with L-NAME (20 mg per kg). Although L-arginine (100 mg per kg) per se did not influence PTZ-induced convulsion, it could attenuate the anticonvulsant effect of celecoxib (5 mg per kg). Our results indicate that celecoxib induces an anticonvulsant effect on clonic seizure threshold that may involve NO pathway.
机译：这项研究旨在检查塞来昔布是否通过调节一氧化氮（NO）途径影响阵挛性癫痫发作阈值。研究了塞来昔布（1-5 mg / kg，p.o.）对雄性瑞士小鼠戊戊四唑（PTZ，50和80 mg / kg，i.p.）诱发的阵挛性癫痫发作的作用。使用NO合酶（NOS）抑制剂，N（G）-ω-硝基-L-精氨酸甲酯（L-NAME，20和50 mg / kg，ip）检查塞来昔布诱导的效应与NO途径的相互作用。 NOS底物L-精氨酸（100和200 mg / kg，ip）。癫痫发作活动发展的标准是，在每公斤PTZ分别服用50和80 mg后，出现广泛性克隆的可能性和抽搐发作潜伏期的延长。塞来昔布（2.5和5 mg / kg）或L-NAME（50 mg / kg）预处理对PTZ引起的阵挛性癫痫发作具有抗惊厥作用。每千克200 mg的L-精氨酸具有惊厥作用。与L-NAME（20 mg / kg）共同使用时，亚有效剂量的celecoxib（1 mg / kg）会产生加性抗惊厥作用。尽管L-精氨酸（100 mg / kg）本身不影响PTZ引起的惊厥，但它可以减弱塞来昔布（5 mg / kg）的抗惊厥作用。我们的结果表明，塞来昔布对阵发性癫痫发作阈值可能具有抗惊厥作用，可能涉及NO途径。

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