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首页> 外文期刊>American Journal of Epidemiology >Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake
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Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake

机译：根据乳腺癌和叶酸摄入的家族史，患者患者的饮酒和乳腺癌风险

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To evaluate the association between alcohol consumption and breast cancer risk in younger women, overall and by family history of breast cancer and folate intake, we prospectively followed 93,835 US women aged 27-44 years in Nurses' Health Study II who had alcohol consumption data in 1991. Alcohol consumption and folate intake were measured by food frequency questionnaire every 4 years. We documented 2,866 incident cases of invasive breast cancer between 1991 and 2011. Alcohol consumption was not associated with breast cancer risk overall (for intake of >= 10 g/day vs. nondrinking, multivariate hazard ratio = 1.07, 95% confidence interval: 0.94, 1.22). When the association was stratified by family history and folate intake, a positive association between alcohol consumption and breast cancer was found among women with a family history and folate intake less than 400 mu g/day (multivariate hazard ratio = 1.82, 95% confidence interval: 1.06, 3.12; P-trend = 0.08). Alcohol consumption was not associated with breast cancer in other categories of family history and folate intake (P-interaction = 0.55). In conclusion, in this population of younger women, higher alcohol consumption was associated with increased risk of breast cancer among those with both a family history of breast cancer and lower folate intake.
机译：评估患者消费和乳腺癌风险之间的关联，整体女性和乳腺癌和叶酸摄入的家族史，我们在护士卫生研究中展示了93,835名美国女性，在护士卫生研究中进行了酗酒数据1991.每4年通过食品频率问卷测量醇消费和叶酸摄入量。我们记录了1991年至2011年间入侵乳腺癌入侵癌症的2,866例。酒精消费总体乳腺癌风险（用于摄入> = 10克/天与非重定，多元危险比= 1.07，95％置信区间：0.94 ，1.22）。当该协会被家庭历史和叶酸摄入分层时，饮酒和乳腺癌之间的阳性关联，患有家族史的女性和叶酸摄入量小于400 mu g /天（多变量危险比= 1.82,95％置信区间：1.06,3.12; p-trend = 0.08）。在其他类别的家庭历史和叶酸摄入（P互动= 0.55）中，酒精消费与乳腺癌无关。总之，在这个年轻女性的人群中，患有乳腺癌家族病史和低叶酸摄入量的人群的乳腺癌的风险增加有关。

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