首页> 外文期刊>Amino acids >Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine
【24h】

Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine

机译:多OMIC接种解码三阴性乳腺癌的悖论:预测,预防和个性化医学的课程

获取原文
获取原文并翻译 | 示例
           

摘要

Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a particularly aggressive type of breast cancer lacking clear diagnostic approach and targeted therapies. Consequently, more than 50% of the TNBC patients die of the metastatic BC within the first 6 months of the diagnosis. In the current study we have hypothesised that multi-omic approach utilising blood samples may lead to discovery of a unique molecular signature of the TNBC subtype. The results achieved demonstrate, indeed, multi-omics as highly promising approach that could be of great clinical utility for development of predictive diagnosis, targeted prevention and treatments tailored to the person-overall advancing the management of the TNBC.
机译:二十一世纪初期的乳腺癌流行病导致约200万份新病例和每年在全球每年注册的疾病相关死亡人数。 特别戏剧性的情况归因于某些特定的患者亚组,例如三阴性乳腺癌(TNBC)。 TNBC是一种特别侵略性的乳腺癌,缺乏明确的诊断方法和有针对性的疗法。 因此,超过50%的TNBC患者在诊断的前6个月内死于转移性BC。 在目前的研究中,我们已经假设利用血液样本的多个内容方法可能导致发现TNBC亚型的独特分子特征。 实现的结果表明,实际上,多OMICS作为高度有前途的方法,可能是用于发展预测诊断的临床效用,针对人的靶向预防和治疗,整体推进TNBC的管理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号