Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock

Trieu Michelle; van Meurs Matijs; van Leeuwen Anoek L. I.; Van Slyke Paul; Hoang Van; Geeraedts Leo M. G. Jr.; Boer Christa; van den Brom Charissa E.

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Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock

机译：血管素，血管发成素-1模拟物，恢复微循环灌注和微血管泄漏，并降低出血休克中的流体复苏要求

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Background: Microcirculatory dysfunction is associated with multiple organ failure and unfavorable patient outcome. We investigated whether therapeutically targeting the endothelial angiopoietin/Tie2 system preserves microvascular integrity during hemorrhagic shock.

机译：背景：微循环功能障碍与多器官失效和不利的患者结果相关。我们研究了治疗靶向血管血管素/ TIE2系统的治疗靶向靶向靶向血管素/ TIE2系统在出血性休克期间保留了微血管完整性。

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《Anesthesiology》 |2018年第2期|共14页
作者
Trieu Michelle; van Meurs Matijs; van Leeuwen Anoek L. I.; Van Slyke Paul; Hoang Van; Geeraedts Leo M. G. Jr.; Boer Christa; van den Brom Charissa E.;
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作者单位

Vrije Univ Amsterdam Med Ctr Dept Anesthesiol Amsterdam Netherlands;

Univ Med Ctr Groningen Dept Pathol &

Med Biol Groningen Netherlands;

Vrije Univ Amsterdam Med Ctr Dept Anesthesiol Amsterdam Netherlands;

Vasomune Therapeut Toronto ON Canada;

Vasomune Therapeut Toronto ON Canada;

Vrije Univ Amsterdam Med Ctr Dept Trauma Surg Amsterdam Netherlands;

Vrije Univ Amsterdam Med Ctr Dept Anesthesiol Amsterdam Netherlands;

Vrije Univ Amsterdam Med Ctr Dept Anesthesiol Amsterdam Netherlands;

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正文语种 eng
中图分类麻醉学;
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1. Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock [J] . Trieu Michelle, van Meurs Matijs, van Leeuwen Anoek L. I., Anesthesiology . 2018,第2期

机译：血管素，血管发成素-1模拟物，恢复微循环灌注和微血管泄漏，并降低出血休克中的流体复苏要求
2. Norepinephrine Decreases Fluid Requirements and Blood Loss While Preserving Intestinal Villi Microcirculation during Fluid Resuscitation of Uncontrolled Hemorrhagic Shock in Mice [J] . Harrois Anatole, Baudry Nathalie, Huet Olivier, Anesthesiology . 2015,第5期

机译：去甲肾上腺素可降低失血量，减少失血量，同时在失血失禁性休克复苏过程中保留肠道绒毛微循环。
3. Laser speckle contrast imaging for assessing microcirculatory changes in multiple splanchnic organs and the gracilis muscle during hemorrhagic shock and fluid resuscitation [J] . Wu Chun-Yu, Yeh Yu-Chang, Chien Chiang-Ting, Microvascular Research: An International Journal . 2015,第Null期

机译：激光散斑对比成像用于评估失血性休克和液体复苏过程中多个内脏器官和腹肌的微循环变化
4. A multi-compartment computer simulation for analysis of fluid resuscitation following hemorrhagic shock [C] . Sheffer, N., Barnea, . 1995

机译：多室计算机模拟，用于分析失血性休克后的液体复苏
5. Induced hypothermia during resuscitation from hemorrhagic shock attenuates microvascular inflammation in the rat mesenteric microcirculation. [D] . Coyan, Garrett Nicholas. 2013

机译：失血性休克复苏过程中诱导的体温过低可减轻大鼠肠系膜微循环中的微血管炎症。
6. Microcirculatory perfusion shows wide inter-individual variation and is important in determining shock reversal during resuscitation in a porcine experimental model of complex traumatic hemorrhagic shock [O] . Sam D. Hutchings, David N. Naumann, Sarah Watts, 2016

机译：微循环灌注显示个体之间的广泛差异在复杂的创伤性出血性休克的猪实验模型中在复苏过程中确定休克逆转方面很重要
7. Microcirculatory perfusion shows wide inter-individual variation and is important in determining shock reversal during resuscitation in a porcine experimental model of complex traumatic hemorrhagic shock [O] . Sam D. Hutchings, David N. Naumann, Sarah Watts, 2016

机译：微循环灌注显示个体之间的广泛差异，在复杂的创伤性出血性休克的猪实验模型中，在复苏过程中确定休克逆转方面很重要

Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock

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