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首页> 外文期刊>Annals of anatomy =: Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft >Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels
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Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

机译：牙科敏感性的分子基础：牙牙细胞是多孔细胞，表达多功能离子通道

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摘要

Odontoblasts are the dental pulp cells responsible for the formation of dentin. In addition, accumulating data strongly suggest that they can also function as sensory cells that mediate the early steps of mechanical, thermic, and chemical dental sensitivity. This assumption is based on the expression of different families of ion channels involved in various modalities of sensitivity and the release of putative neurotransmitters in response to odontoblast stimulation which are able to act on pulp sensory nerve fibers. This review updates the current knowledge on the expression of transient-potential receptor ion channels and acid-sensing ion channels in odontoblasts, nerve fibers innervating them and trigeminal sensory neurons, as well as in pulp cells. Moreover, the innervation of the odontoblasts and the interrelationship been odontoblasts and nerve fibers mediated by neurotransmitters was also revisited. These data might provide the basis for novel therapeutic approaches for the treatment of dentin sensibility and/or dental pain. (C) 2017 Elsevier GmbH. All rights reserved.
机译：Odontoblasts是负责牙本质形成的牙髓细胞。此外，强烈累积数据表明它们还可以用作介导机械，热和化学牙齿敏感性早期步骤的感官细胞。该假设基于各种敏感性敏感性型号的不同离子通道的表达，以及响应能够在纸浆感觉神经纤维上作用的幼儿细胞刺激释放推定的神经递质。本次综述更新了关于瞬态电位受体离子通道和酸感测离子通道的目前的知识，所述神经纤维，所述神经纤维，所述神经纤维和所述三血管感觉神经元以及纸浆细胞。此外，还重访了牙牙细胞的支配和相互关系的异常卵细胞和神经纤维也被重新判断。这些数据可能为治疗牙本质敏感性和/或牙科疼痛的新治疗方法提供基础。 （c）2017 Elsevier GmbH。版权所有。

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