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首页> 外文期刊>Annual review of cell and developmental biology >Synthetic Developmental Biology: Understanding Through Reconstitution
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Synthetic Developmental Biology: Understanding Through Reconstitution

机译：综合发育生物学：通过重建理解

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Reconstitution is an experimental strategy that seeks to recapitulate biological events outside their natural contexts using a reduced set of components. Classically, biochemical reconstitution has been extensively applied to identify the minimal set of molecules sufficient for recreating the basic chemistry of life. By analogy, reconstitution approaches to developmental biology recapitulate aspects of developmental events outside an embryo, with the goal of revealing the basic genetic circuits or physical cues sufficient for recreating developmental decisions. The rapidly growing repertoire of genetic, molecular, microscopic, and bioengineering tools is expanding the complexity and precision of reconstitution experiments. We review the emerging field of synthetic developmental biology, with a focus on the ways in which reconstitution strategies and new biological tools have enhanced our modern understanding of fundamental questions in developmental biology.
机译：重构是一种实验策略，旨在使用减少的组件来重新承载其自然背景之外的生物事件。 经典地，已经广泛地应用生化重构以确定足以重建生命基本化学的最小分子集。 通过类比，重构生物学方法旨在概括了胚胎之外的发育事件的方面，其目的是揭示足以重建发育决策的基本遗传电路或物理线索。 遗传，分子，微观和生物工程工具的快速增长的曲目正在扩大重构实验的复杂性和精确性。 我们审查了综合发育生物学领域，重点是重建战略和新的生物工具提高了对发展生物学的基本问题的现代理解。

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