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首页> 外文期刊>Annual review of cell and developmental biology >Caveolae: Structure, Function, and Relationship to Disease
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Caveolae: Structure, Function, and Relationship to Disease

机译：Caveolae：结构，功能和与疾病的关系

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摘要

The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma membrane, are the most abundant surface subdomains of many mammalian cells. The cellular functions of caveolae have long remained obscure, but a new molecular understanding of caveola formation has led to insights into their workings. Caveolae are formed by the coordinated action of a number of lipid-interacting proteins to produce a microdomain with a specific structure and lipid composition. Caveolae can bud from the plasma membrane to form an endocytic vesicle or can flatten into the membrane to help cells withstand mechanical stress. The role of caveolae as mechanoprotective and signal transduction elements is reviewed in the context of disease conditions associated with caveola dysfunction.
机译：真核细胞的血浆膜不是简单的脂质和蛋白质，但是用重要功能分化为亚域。 Caveolae，血浆膜中的小型凹坑，是许多哺乳动物细胞的最丰富的表面亚域。 Caveolae的细胞功能长度仍然模糊不清，但对Caveola形成的新分子理解导致其工作中的洞察力。 通过许多脂质相互作用蛋白的协调作用形成Caveolae，以产生具有特定结构和脂质组合物的微髓。 Caveolae可以从血浆膜中萌芽，形成内吞囊泡，或者可以扁平到膜中以帮助细胞承受机械应力。 Caveolae作为机械防护和信号转导元素的作用在与Caveola功能障碍相关的疾病病症的背景下进行了审查。

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