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首页> 外文期刊>Annual review of cell and developmental biology >Multitasking: Dual Leucine Zipper Bearing Kinases in Neuronal Development and Stress Management
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Multitasking: Dual Leucine Zipper Bearing Kinases in Neuronal Development and Stress Management

机译：多任务：双亮氨酸拉链轴承激酶在神经元发展和应力管理中

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摘要

The dual leucine zipper–bearing kinase (DLK) and leucine zipper–bearing kinase (LZK) are evolutionarily conserved MAPKKKs of the mixed-lineage kinase family.Acting upstream of stress-responsive JNK and p38 MAP kinases, DLK and LZK have emerged as central players in neuronal responses to a variety of acute and traumatic injuries.Recent studies also implicate their function in astrocytes, microglia, and other nonneuronal cells, reflecting their expanding roles in the multicellular response to injury and in disease.Of particular note is the potential link of these kinases to neurodegenerative diseases and cancer.It is thus critical to understand the physiological contexts under which these kinases are activated, as well as the signal transduction mechanisms that mediate specific functional outcomes.In this review we first provide a historical overview of the biochemical and functional dissection of these kinases.We then discuss recent findings on regulating their activity to enhance cellular protection following injury and in disease, focusing on but not limited to the nervous system.
机译：双亮氨酸抗纤维激酶（DLK）和亮氨酸拉链激酶（LZK）正在进行加速度保守的混合谱系Kinase系列。应激响应JNK和P38映射激酶的上游，DLK和LZK已成为中央神经元对各种急性和创伤性损伤的作用者的作用者也是在星形胶质细胞，小胶质细胞和其他非生物细胞中致力于其在多细胞反应中的损伤和疾病中的扩张作用。特别说明是潜在的环节这些激酶对神经变性疾病和癌症。这对于了解这些激酶被激活的生理环境以及调节特定功能结果的信号转导机制至关重要。在这篇评论中我们首先提供了生物化学的历史概述这些激酶的功能解剖。然后，我们讨论了最近关于调节他们的活动以增强Cellu的结果在伤害和疾病之后的保护，关注但不限于神经系统。

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