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首页> 外文期刊>Animal >Effects of trace mineral amount and source on aspects of oxidative metabolism and responses to intramammary lipopolysaccharide challenge in midlactation dairy cows
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Effects of trace mineral amount and source on aspects of oxidative metabolism and responses to intramammary lipopolysaccharide challenge in midlactation dairy cows

机译：痕量矿物量的影响及源对氧化代谢方面的影响，对中际乳制奶牛胎儿脂多糖攻击的反应

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Trace minerals have important roles in immune function and oxidative metabolism; however, little is known about the relationships between supplementation level and source with outcomes in dairy cattle. Multiparous Holstein cows (n=48) beginning at 60 to 140 days in milk were utilized to determine the effects of trace mineral amount and source on aspects of oxidative metabolism and responses to intramammary lipopolysaccharide (LPS) challenge. Cows were fed a basal diet meeting National Research Council (NRC) requirements except for no added zinc (Zn), copper (Cu) or manganese (Mn). After a 4-week preliminary period, cows were assigned to one of four topdress treatments in a randomized complete block design with a 2×2 factorial arrangement of treatments: (1) NRC inorganic (NRC levels using inorganic (sulfate-based) trace mineral supplements only); (2) NRC organic (NRC levels using organic trace mineral supplements (metals chelated to 2-hydroxy-4-(methythio)-butanoic acid); (3) commercial inorganic (approximately 2×NRC levels using inorganic trace mineral supplements only; and (4) commercial organic (commercial levels using organic trace mineral supplements only). Cows were fed the respective mineral treatments for 6 weeks. Treatment effects were level, source and their interaction. Activities of super oxide dismutase and glutathione peroxidase in erythrocyte lysate and concentrations of thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) in plasma were measured as indices of oxidative metabolism. Effects of treatment on those indices were not significant when evaluated across the entire experimental period. Plasma immunoglobulin G level was higher in cows supplemented with organic trace minerals over the entire treatment period; responses assessed as differences of before and after Escherichia coli J5 bacterin vaccination at the end of week 2 of treatment period were not significant. Cows were administered an intramammary LPS challenge during week 5; during week 6 cows fed commercial levels of Zn, Cu and Mn tended to have higher plasma TAC and cows fed organic sources had decreased plasma TBARS. After the LPS challenge, the extent and pattern of response of plasma cortisol concentrations and clinical indices (rectal temperature and heart rate) were not affected by trace mineral level and source. Productive performance including dry matter intake and milk yield and composition were not affected by treatment. Overall, results suggest that the varying level and source of dietary trace minerals do not have significant short-term effects on oxidative metabolism indices and clinical responses to intramammary LPS challenge in midlactation cows.
机译：微量矿物质在免疫功能和氧化代谢中具有重要作用;然而，关于乳制品牛的辅作水平和来源之间的关系很少。利用60至140天开始的多体Holstein牛（n = 48）用于确定痕量矿物质量和源于氧化代谢的方面的影响，以及对患胎型脂多糖（LPS）攻击的反应。除了没有添加的锌（Zn），铜（Cu）或锰（Mn）外，奶牛喂养了国家研究委员会（NRC）要求的基础饮食。经过4周的初步期后，奶牛被分配到随机完整块设计中的四个顶层治疗中的一个，具有2×2因子治疗排列：（1）NRC无机（使用无机（硫酸盐）的NRC水平（硫酸盐）痕量矿物质仅补充剂）; （2）NRC有机物（使用有机痕量矿物质补充剂（金属螯合到2-羟基-4-（甲基） - 丁基酸的NRC水平）;（3）仅使用无机痕量矿物质补充剂的商业无机（约2×NRC水平;和（4）商业有机（仅使用有机痕量矿物质补充剂的商业水平）。奶牛喂养各自的矿物治疗6周。治疗效果是水平，来源及其相互作用。红细胞裂解物中超氧化物歧化酶和谷胱甘肽过氧化物酶的活性和浓度测量硫氨基吡咯酸反应性物质（TBARS）和血浆中的总抗氧化能力（TAC）作为氧化代谢的索引。在整个实验期间评估时，治疗对这些指数的影响并不重要。奶牛的血浆免疫球蛋白G水平较高在整个治疗期间补充有机痕量矿物质;评估评估为大肠杆菌在eScherichia co之前和之后的差异李J5治疗期结束时的细菌疫苗接种不显着。奶牛在第5周内进行嵌入式LPS挑战;在第6周期间，喂养Zn，Cu和Mn的商业水平倾向于具有更高的血浆TAC，奶牛饲喂有机源减少了血浆TBAR。在LPS挑战之后，血浆皮质醇浓度和临床指数（直肠温度和心率）的程度和模式不受痕量矿物水平和来源的影响。生产性能，包括干物质摄入和牛奶产量和组合物不受治疗的影响。总体而言，结果表明膳食微量矿物质的不同水平和来源对氧化代谢指数没有显着的短期影响，对中际奶牛的脑内LPS挑战临床反应。

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