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首页> 外文期刊>Applied health economics and health policy >ReCell Spray-On Skin System for Treating Skin Loss, Scarring and Depigmentation after Burn Injury: A NICE Medical Technology Guidance
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ReCell Spray-On Skin System for Treating Skin Loss, Scarring and Depigmentation after Burn Injury: A NICE Medical Technology Guidance

机译：恢复喷涂皮肤系统治疗烧伤后的皮肤损失，疤痕和脱毛：一种很好的医疗技术指导

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The gold standard treatment for deep burns is an autologous skin graft; in larger burns this may be meshed to increase the area covered. However, long-term aesthetic and functional outcomes of graft scars may be poor. ReCell? is a medical device that processes skin samples in the operating theatre into a cell suspension to be sprayed or dripped onto a wound. It is claimed to improve healing and scar appearance. This device was evaluated by the National Institute for Health and Care Excellence (NICE) Medical Technologies Evaluation Programme. Two groups were defined: ReCell compared to conventional dressings in shallower burns, and meshed grafts plus ReCell compared to meshed grafts alone in larger deeper burns. The manufacturer's clinical evidence submission included three papers and eight conference abstracts. The External Assessment Centre (EAC) excluded two of these and added seven abstracts. In general, the evidence did not fit the defined groups, but suggested that ReCell was clinically comparable to skin grafts for partial thickness burns; however, ReCell is not used in this way in the UK. The manufacturer submitted an economic model in which ReCell treatment of partial thickness bums reduced the requirement for later skin grafts. This indicated that ReCell alone was cost saving in comparison to conventional dressings. The EAC indicated that this model was clinically inappropriate, but data were not available to populate a new model. NICE Medical Technologies Guidance 21 recommended that additional research was needed to address the uncertainties regarding the potential benefits of ReCell.
机译：深度烧伤的黄金标准处理是一种自体皮肤移植物;在较大的烧伤中，这可能被啮合以增加所覆盖的面积。然而，移植疤痕的长期美学和功能性结果可能是差。休息？是一种医疗器械，其将手术室中的皮肤样品加工成待喷涂或滴在伤口上的细胞悬浮液中。据说它可以改善愈合和瘢痕外观。该设备由国家健康和护理研究所评估（尼斯）医疗技术评估计划评估。定义了两组：与较浅的燃烧中的常规敷料相比，与啮合的移植物加上啮合的移植物相比，与啮合的移植物相比，单独的较大燃烧。制造商的临床证据提交包括三篇论文和八个会议摘要。外部评估中心（EAC）排除了其中的两个并添加了七个摘要。一般而言，证据不符合规定的群体，但建议雷尔结合在临床上与用于部分厚度燃烧的皮肤移植物;但是，在英国没有以这种方式使用雷厄尔。制造商提交了经济模型，其中部分厚度损坏的综合处理减少了后期皮肤移植的要求。这表明与常规敷料相比，单独的雷厄尔是节省成本的。 EAC表示，此模型在临床上是不合适的，但数据无法填充新模型。良好的医疗技术指导21建议需要额外的研究来解决关于历史潜在利益的不确定性。

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