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首页> 外文期刊>Advanced drug delivery reviews >Clinical perspectives on pulmonary systemic and macromolecular delivery.
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Clinical perspectives on pulmonary systemic and macromolecular delivery.

机译：肺部全身和大分子递送的临床观点。

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摘要

The large epithelial surface area, the high organ vascularization, the thin nature of the alveolar epithelium and the immense capacity for solute exchange are factors that led the lung to serve as an ideal administration route for the application of drugs for treatment of systemic disorders. However, the deposition behaviour of aerosol particles in the respiratory tract depends on a number of physical (e.g. properties of the particle), chemical (e.g. properties of the drug) and physiological (e.g. breathing pattern, pulmonary diseases) factors. If these are not considered, it will not be possible to deposit a reproducible and sufficient amount of drug in a predefined lung region by means of aerosol inhalation. The lack of consideration of such issues led to many problems in inhalation drug therapy for many years mainly because physiological background of aerosol inhalation was not fully understood. However, over the last 20 years, there has been considerable progress in aerosol research and in the understanding of the underlying mechanisms of particle inhalation and pulmonary particle deposition. As a consequence, an increasing number of studies have been performed for the lung administration of drugs using a variety of different inhalation techniques. This review describes the physical and in part some of the physiological requirements that need to be considered for the optimization of pulmonary drug delivery to target certain lung regions.
机译：大的上皮表面积，高的器官血管化，肺泡上皮的稀薄性质和巨大的溶质交换能力是促使肺部成为治疗系统性疾病药物应用的理想给药途径的因素。然而，气溶胶颗粒在呼吸道中的沉积行为取决于许多物理（例如，颗粒的性质），化学（例如，药物的性质）和生理（例如，呼吸方式，肺部疾病）因素。如果不考虑这些因素，将不可能通过气雾剂吸入在预定的肺区域中沉积可重现和足够量的药物。多年来对这些问题的缺乏考虑导致了吸入药物治疗中的许多问题，这主要是因为尚未完全了解气雾吸入的生理背景。然而，在过去的20年中，在气雾剂研究以及对颗粒吸入和肺部颗粒沉积的潜在机制的理解方面取得了长足的进步。结果，已经使用多种不同的吸入技术对药物的肺部给药进行了越来越多的研究。这篇综述描述了优化肺部药物递送以靶向某些肺区域所需的物理和部分生理要求。

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