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首页> 外文期刊>Acta Poloniae Pharmaceutica: Durg Research >Determination of ethanol content in medicated syrups by static headspace gas chromatography
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Determination of ethanol content in medicated syrups by static headspace gas chromatography

机译：静态顶空气相色谱法测定药用糖浆中的乙醇含量

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摘要

Liquid drug preparations are the most convenient for pediatric patients. Unfortunately, these formulations very often contain ethanol, which may have an impact on children development. Moreover, medicines containing alcohol may cause undesirable interactions in conjunction with other drugs. This work reports complete validated method for the quantitation of ethanol in commercial medicated syrups. For determination of ethanol headspace gas chromatography and different methods of quantitative analysis were used. The analyzed samples of commercial medicated syrups available on the home marked contained from 3.37 to 8.65% (v/v) of ethanol. The estimated theoretical values of blood ethanol concentration for children after single recommended dose ingestion were at least twice lower than 0.125 g/mL. The process of validation showed that the applied GC method is selective, sensitive, linear and precise. The use of internal standard makes it accurate. The developed method could be considered as an analytical tool for the quality control of various liquid drug preparations.
机译：液体药物制剂最适合小儿患者。不幸的是，这些配方经常含有乙醇，这可能对儿童发育产生影响。此外，含酒精的药物可能会与其他药物一起引起不良相互作用。这项工作报告了用于商业药浆中乙醇定量的完整验证方法。为了测定乙醇顶空气相色谱法和定量分析方法，采用了不同的方法。经分析，可在标有商标的房屋上买到的商业药用糖浆样品中含有3.37至8.65％（v / v）的乙醇。单次推荐剂量摄入后儿童血液乙醇浓度的估计理论值至少比0.125 g / mL低两倍。验证过程表明，所应用的气相色谱方法具有选择性，灵敏，线性和精确性。使用内标使其准确。所开发的方法可视为各种液体药物制剂质量控制的分析工具。

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