...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Compromised MAPK signaling in human diseases: an update
【24h】

Compromised MAPK signaling in human diseases: an update

机译：损害人类疾病中的MAPK信号传导：更新

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH2-terminal kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes are serine-threonine protein kinases that regulate various cellular activities including proliferation, differentiation, apoptosis or survival, inflammation, and innate immunity. The compromised MAPK signaling pathways contribute to the pathology of diverse human diseases including cancer and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The JNK and p38 MAPK signaling pathways are activated by various types of cellular stress such as oxidative, genotoxic, and osmotic stress as well as by proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin 1 beta. The Ras-Raf-MEK-ERK signaling pathway plays a key role in cancer development through the stimulation of cell proliferation and metastasis. The p38 MAPK pathway contributes to neuroinflammation mediated by glial cells including microglia and astrocytes, and it has also been associated with anticancer drug resistance in colon and liver cancer. We here summarize recent research on the roles of MAPK signaling pathways in human diseases, with a focus on cancer and neurodegenerative conditions.
机译：哺乳动物中的丝裂原激活的蛋白激酶（MAPK）包括C-JUM NH2-末端激酶（JNK），P38MAPK和细胞外信号调节激酶（ERK）。这些酶是丝氨酸苏氨酸蛋白激酶，其调节各种细胞活性，包括增殖，分化，凋亡或存活，炎症和先天免疫。受损的MAPK信号通路有助于各种人类疾病的病理，包括癌症和神经变性疾病，如阿尔茨海默病，帕金森病和肌营养的外侧硬化。 JNK和P38 MAPK信号传导途径被各种类型的细胞应激激活，例如氧化，遗传毒性和渗透压，以及促炎细胞因子，如肿瘤坏死因子-α和白细胞介素1β。 RAS-RAF-MEK-ERK信号通路通过刺激细胞增殖和转移来发挥癌症发展中的关键作用。 P38 MAPK途径有助于神经胶质细胞介导的神经炎细胞，包括微胶质细胞和星形胶质细胞，它也与结肠和肝癌中的抗癌耐药有关。我们在这里总结了近期MAPK信号传导途径在人类疾病中的作用的研究，重点是癌症和神经变性条件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号