...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Asia Pacific journal of clinical nutrition >High prevalence of vitamin B-12 insufficiency in patients with Crohn's disease
【24h】

High prevalence of vitamin B-12 insufficiency in patients with Crohn's disease

机译：克罗恩病患者维生素B-12不足的高患病率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Objectives: In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Most frequently affected is the distal ileum, where vitamin B-12 is specifically absorbed. Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. In this study, we have studied the vitamin B-12 status in CD patients. Methods and Study Design: Forty eight patients with CD were evaluated for their food intake, and circulating concentrations of vitamin B-12, folic acid, and homocysteine (Hcy) as a sensitive marker for the insufficiency of these vitamins and a risk factor of atherosclerosis. Results: Plasma Hcy concentration was significantly correlated with serum vitamin B-12 concentration alone, and 60.4 % of the subjects had hyperhomocysteinemia. Receiver Operating Characteristics (ROC) analysis showed that serum concentration of vitamin B-12, but not folic acid, predicted hyperhomocysteinemia. Their intake of vitamin B-12 was much higher than the Japanese RDA, but not correlated with blood concentrations of vitamin B-12 or Hcy, probably due to malabsorption. Conclusions: Vitamin B-12 insufficiency and hyperhomocysteinemia were highly prevalent in CD patients. Recently, the significance of extra-intestinal complications of CD has been increasingly recognized, and our finding is likely to be of clinical importance.
机译：背景和目标：在克罗恩病（CD）中，属于炎症性肠病，在大多数情况下都参与小肠。最常受影响的是远端回肠，维生素B-12特异性吸收。因此，镉患者中，维生素B-12的吸收不可能发生。在这项研究中，我们研究过CD患者的维生素B-12状态。方法和研究设计：对其食物摄入的48例CD患者，以及维生素B-12，叶酸和同型半胱氨酸（HCY）的循环浓度，作为这些维生素不足的敏感标志物和动脉粥样硬化的危险因素。结果：单独的血浆HCY浓度与血清维生素B-12浓度显着相关，60.4％的受试者具有高胱氨酸血症。接收器操作特征（ROC）分析表明，维生素B-12的血清浓度，但不是叶酸，预测的高纤维症。他们的维生素B-12的摄入远高于日本的RDA，但不能与维生素B-12或Hcy的血液浓度相关，这可能是由于不吸臭的。结论：维生素B-12功能不全，高纤维素血症在CD患者中普遍普遍。最近，CD的肠外并发症的重要性已经越来越认识到，我们的发现可能具有临床重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号