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Novel application for electrochemotherapy: Immersion of nasal cavity in dog

机译：电化学疗法新应用：狗鼻腔浸没

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Electrochemotherapy is a new modality of local cancer treatment that increases the delivery of chemotherapy drugs into tumor cells by applying intense electric fields. This novel electrochemotherapy application was applied as an adjuvant to surgery and eliminated intranasal tumors in dog. The treatment challenges are the surgery limitations due to anatomy and residual tumor in the bone cavity. Most of the tumoral mass on nasal cavity was surgically removed. The internal nasal cavity was immersed in liquid and bleomycin before applying electric field. The solution was necessary to increase the superficial contact between plate electrodes and residual tumor. The numerical study demonstrated electrochemotherapy efficiency in different clinical situations. The proximity between electrodes and bone (<3 mm) and bone irregularities affect the electric field distribution on tumoral tissue. The tumoral tissue around bone protuberances tends to be eliminated. Electrochemotherapy with plate electrodes inside the cavity might not be effective. Different values of electric conductivity solution were studied; the ideal value was 0.5 S/m. The numerical and experimental results confirm the successful application of electrochemotherapy on dog nasal cavity.
机译：电化学疗法是一种新的癌症治疗方式，通过施加强烈的电场将化疗药物递送到肿瘤细胞中。该新型电化学疗法应用被用作手术的佐剂，并在狗中消除鼻内肿瘤。治疗挑战是由于骨腔中的解剖和残留肿瘤引起的手术限制。鼻腔上的大多数肿瘤肿块在手术上除去。在施加电场之前，内部鼻腔浸入液体和玻璃霉素中。该解决方案是必要的，以增加板电极和残留肿瘤之间的表面接触。数值研究表明了不同临床情况下的电化学疗效。电极和骨（<3mm）和骨不规则之间的接近度影响肿瘤组织上的电场分布。骨突起周围的肿瘤组织趋于消除。电化学疗法在腔内的板电极可能无效。研究了电导率溶液的不同值;理想值为0.5 s / m。数值和实验结果证实了电化学疗法在狗鼻腔中的应用。

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