Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells

Chen Nathan H.; Ong Cheryl-lynn Y.; OSullivan Jonathan; Ibranovic Ines; Davey Krystelle; Edwards Jennifer L.; McEwan Alastair G.

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Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells

机译：两种不同的L-乳酸脱氢酶在宫颈上皮细胞中Neisseria淋病术的存活中起作用

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L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells.

机译：L-乳酸盐是宿主生物中许多核桃中的一种丰富的代谢物，代表了诸如Neisseria淋病的细菌病原体的重要碳源。在该研究中，我们描述了一种含有的含铁硫簇的L-乳酸脱氢酶（LUTACB），其不同于黄蛋白L-乳酸脱氢酶（LLDD）。发现Lutacb的表达被铁正面调节，而LLDD在铁限制条件下更高度表达。 LutacB和LLDD的功能作用反映在生长的体外研究中，并在原代宫颈上皮细胞中的N淋耳藻的存活中。

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《Autonomic neuroscience: basic & clinical》 |2019年第1期|共5页
作者
Chen Nathan H.; Ong Cheryl-lynn Y.; OSullivan Jonathan; Ibranovic Ines; Davey Krystelle; Edwards Jennifer L.; McEwan Alastair G.;
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作者单位

Univ Queensland Sch Chem &

Mol Biosci Cooper Rd St Lucia Qld 4072 Australia;

Univ Queensland Sch Chem &

Mol Biosci Cooper Rd St Lucia Qld 4072 Australia;

Univ Queensland Sch Chem &

Mol Biosci Cooper Rd St Lucia Qld 4072 Australia;

Univ Queensland Sch Chem &

Mol Biosci Cooper Rd St Lucia Qld 4072 Australia;

Univ Queensland Sch Chem &

Mol Biosci Cooper Rd St Lucia Qld 4072 Australia;

Nationwide Childrens Hosp Abigail Wexner Res Inst Ctr Microbial Pathogenesis Columbus OH USA;

Univ Queensland Sch Chem &

Mol Biosci Cooper Rd St Lucia Qld 4072 Australia;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
gonococcus; intracellular metabolism; iron regulation; lactate; respiration;

机译：gonococcus;细胞内代谢;铁调节;乳酸;呼吸;

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专利

1. Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells [J] . The Journal of Infectious Diseases . 2020,第3期

机译：两种不同的L-乳酸脱氢酶在宫颈上皮细胞的Neisseria淋病术的存活中起作用
2. Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells [J] . Chen Nathan H., Ong Cheryl-lynn Y., OSullivan Jonathan, Autonomic neuroscience: basic & clinical . 2019,第1期

机译：两种不同的L-乳酸脱氢酶在宫颈上皮细胞中Neisseria淋病术的存活中起作用
3. A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells. [J] . John M Atack, Ines Ibranovic, Cheryl-Lynn Y Ong, The Journal of Infectious Diseases . 2014,第8期

机译：乳酸脱氢酶在淋病奈瑟氏菌在人多形核白细胞和宫颈上皮细胞中的存活中的作用。
4. Improvement of mammalian cell survival by inhibition of ice/ced-3 protease, playing key role in apoptosis [C] . Satoshi Terada, Katsuyuki Fukuoka, Testsuo Fujita, Asia-Pacific biochemical engineering conference;APBIOCHEC'97 . 1997

机译：通过抑制ice / ced-3蛋白酶改善哺乳动物细胞的存活，在细胞凋亡中起关键作用
5. The role of ERBB receptors in Neisseria gonorrhoeae invasion of genital epithelial cells. [D] . Swanson, Karen Victoria. 2010

机译：ERBB受体在淋病奈瑟氏球菌侵袭生殖器上皮细胞中的作用。
6. A Role for Lactate Dehydrogenases in the Survival of Neisseria gonorrhoeae in Human Polymorphonuclear Leukocytes and Cervical Epithelial Cells [O] . John M. Atack, Ines Ibranovic, Cheryl-Lynn Y. Ong, -1

机译：乳酸脱氢酶在淋病奈瑟菌在人多形核白细胞和宫颈上皮细胞中的存活中的作用
7. Distinct Proinflammatory Host Responses to Neisseria gonorrhoeae Infection in Immortalized Human Cervical and Vaginal Epithelial Cells [O] . Fichorova, Raina Nakova, Desai, Pragnya Jasvantrai, Gibson, Frank C., 2001

机译：在永生化的人宫颈和阴道上皮细胞中对淋病奈瑟菌感染的不同促炎宿主反应
8. Specificity of Inhibition of Epithelial Cell Adhesion of 'Neisseria gonorrhoeae'. [R] . Tramont, E. C. 1976

机译：抑制淋病奈瑟菌上皮细胞粘附的特异性。

Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells

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