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首页> 外文期刊>Annual Review of Immunology >Finding a Way Out: S1P Signaling and Immune Cell Migration
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Finding a Way Out: S1P Signaling and Immune Cell Migration

机译：寻找出路：S1P信号和免疫细胞迁移

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The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune response. Drugs targeting S1P signaling have been remarkably successful in treatment of multiple sclerosis, and they have shown promise in clinical trials for colitis and psoriasis. One mechanism of these drugs is to block lymphocyte exit from lymph nodes, where lymphocytes are initially activated, into circulation, from which lymphocytes can reach sites of inflammation. Indeed, S1P can be considered a circulation marker, signaling to immune cells to help them find blood and lymphatic vessels, and to endothelial cells to stabilize the vasculature. That said, S1P plays pleiotropic roles in the immune response, and it will be important to build an integrated view of how S1P shapes inflammation. S1P can function so effectively because its distribution is exquisitely tightly controlled. Here we review how S1P gradients regulate immune cell exit from tissues, with particular attention to key outstanding questions in the field.
机译：信号传导脂质鞘氨醇1-磷酸（S1P）在免疫应答中起着关键作用。靶向S1P信号传导的药物在治疗多发性硬化症时已经取得了显着成功，并且他们在结肠炎和牛皮癣的临床试验中显示了许可。这些药物的一种机制是阻断淋巴细胞从淋巴结出口，其中淋巴细胞最初被激活，循环，淋巴细胞可以从中达到炎症的位点。实际上，S1P可以被认为是循环标记物，信号传递到免疫细胞，以帮助它们找到血液和淋巴管，并向内皮细胞稳定脉管系统。也就是说，S1P在免疫应答中起着抗脂病作用，并且建立一个S1P如何形状炎症的综合图一致。 S1P可以如此有效地起作用，因为它的分布是精致的控制。在这里，我们回顾了S1P梯度如何调节免疫细胞从组织中出口，特别注意该领域的关键突出问题。

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