Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

Lionakis Michail S.; Levitz Stuart M.

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Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

机译：宿主控制真菌感染：基础研究和人队的课程

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In the last few decades, the AIDS pandemic and the significant advances in the medical management of individuals with neoplastic and inflammatory conditions have resulted in a dramatic increase in the population of immunosuppressed patients with opportunistic, life-threatening fungal infections. The parallel development of clinically relevant mouse models of fungal disease and the discovery and characterization of several inborn errors of immune-related genes that underlie inherited human susceptibility to opportunistic mycoses have significantly expanded our understanding of the innate and adaptive immune mechanisms that protect against ubiquitous fungal exposures. This review synthesizes immunological knowledge derived from basic mouse studies and from human cohorts and provides an overview of mammalian antifungal host defenses that show promise for informing therapeutic and vaccination strategies for vulnerable patients.

机译：在过去的几十年中，艾滋病大流行和肿瘤和炎症病症的个体医学管理的重要进展导致了免疫抑制患者的巨大增加，机会主义，危及生命的真菌感染。临床相关的小鼠模型的真菌疾病的并行发展以及对有利于机会主义型肌肉的影响的免疫相关基因的几种未生命的基因的发现和表征已经显着扩大了我们对防止普遍存气的天生和适应性免疫机制的理解曝光。本综述综合了源自基本小鼠研究和人类群体的免疫学知识，并提供了哺乳动物抗真菌宿主防御的概述，表明了解弱势患者的治疗和疫苗接种策略。

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来源
《Annual Review of Immunology》 |2018年第2018期|共35页
作者
Lionakis Michail S.; Levitz Stuart M.;
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作者单位

NIAID Fungal Pathogenesis Sect Lab Clin Immunol &

Microbiol NIH Bethesda MD 20892 USA;

Univ Massachusetts Sch Med Dept Med Worcester MA 01655 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
fungi; antifungal immunity; monogenic disorders; acquired immunodeficiencies; fungal vaccines; immunotherapy;

机译：真菌;抗真菌免疫;单身疾病;获得的免疫缺陷;真菌疫苗;免疫疗法;

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1. Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts [J] . Lionakis Michail S., Levitz Stuart M. Annual Review of Immunology . 2018,第期

机译：宿主控制真菌感染：基础研究和人队的课程
2. Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya [J] . Susanne H Hodgson, Elizabeth Juma, Amina Salim, Malaria Journal . 2015,第1期

机译：从在肯尼亚内罗毕进行的首次人类疟疾控制研究的经验教训
3. Human host genetic factors innontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon-gamma-dependent signaling [J] . Haverkamp MH, van Dissel JT, Holland SM Microbes and infection . 2006,第4期

机译：非结核分枝杆菌感染的人类宿主遗传因素：影响先天和适应性免疫的单基因疾病的教训以及干扰素-γ依赖性信号传导中分子缺陷的教训
4. A Retrospective Cohort Study on the Invasive Fungal Infection in the Preterm Infants [C] . Dan Dang, Xin Mu, Jian Tang, International Conference on Applied Mathematics, Modelling and Statistics Application . 2018

机译：早产儿侵袭性真菌感染的回顾性队列研究
5. Examining the interaction between human immunodeficiency virus and malaria infections using data from prospective cohort studies in Uganda. [D] . Malamba, Samuel Sewava. 2007

机译：使用来自乌干达的前瞻性队列研究的数据来检查人类免疫缺陷病毒和疟疾感染之间的相互作用。
6. Lessons learnt from the first controlled human malaria infection study conducted in Nairobi Kenya [O] . Susanne H Hodgson, Elizabeth Juma, Amina Salim, 2015

机译：从在肯尼亚内罗毕进行的首次人类疟疾控制研究的经验教训
7. A study on the pathogenesis of visceral fungal infections. A risk index for visceral fungal infections in immunocompromised hosts. (1) [O] . Mayumi Mochizuki, Setuko Murase, Fumiya Tomonaga, 1989

机译：内脏真菌感染的发病机制研究。免疫功能性宿主中内脏真菌感染的风险指标。（1）
8. Cohort Study of Health Effects of HTLV-I Infection in Jamaican Children and their Associations with Viral, Immunologic and Host Genetic Markers [R] . Elizabeth Margaret, M. 2002

机译：牙买加儿童HTLV-I感染对健康影响的队列研究及其与病毒，免疫和宿主遗传标记的关联

Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

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