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The Microbiome and Food Allergy

机译：微生物组和食物过敏

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The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters antigens derived from an estimated 10(14) commensal microbes and greater than 30 kg of food proteins yearly. It must distinguish these harmless antigens from potential pathogens and mount the appropriate host immune response. Local and systemic hyporesponsiveness to dietary antigens, classically referred to as oral tolerance, comprises a distinct complement of adaptive cellular and humoral immune responses. It is increasingly evident that a functional epithelial barrier engaged in intimate interplay with innate immune cells and the resident microbiota is critical to establishing and maintaining oral tolerance. Moreover, innate immune cells serve as a bridge between the microbiota, epithelium, and the adaptive immune system, parlaying tonic microbial stimulation into signals critical for mucosal homeostasis. Dysregulation of gut homeostasis and the subsequent disruption of tolerance therefore have clinically significant consequences for the development of food allergy.
机译：肠道相关淋巴组织（GALT）面临着相当大的挑战。它遇到从估计的10（14）个共生微生物和每年大于30千克食物蛋白的抗原。它必须将这些无害的抗原与潜在病原体区分开，并安装适当的宿主免疫应答。局部和系统性低反向性与饮食抗原，经典称为口腔耐受性，包括自适应细胞和体液免疫反应的明显补充。越来越明显明显，与先天免疫细胞和驻留的微生物生物与静物相互作用的功能性上皮屏障对于建立和维持口腔耐受性至关重要。此外，先天免疫细胞用作微生物群，上皮和自适应免疫系统之间的桥梁，使帕拉扬的滋补微生物刺激成为对粘膜稳态至关重要的信号。因此，肠道稳态的失调和随后的耐受性对食物过敏的发展具有临床显着的影响。

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