Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7-[4-(2,6-dimethyl/dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid

Yadav Radeep; Hada Sonal; Yadav Dinesh Kumar; Kumari Neetu

首页> 外文期刊>Indian Journal of Chemistry, Section B. Organic Including Medicinal >Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7-[4-(2,6-dimethyl/dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid

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Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7-[4-(2,6-dimethyl/dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid

机译：1-环丙基-7- [4-（2,6-二甲基/二甲氧基嘧啶-2-基二亚苄酯-2-基二甲酰基）-3-氟-4-4-氟-4-的合成和1,3-二酮衍生物的合成和抗菌活性。-6-氟-4- Oxo-1,4-二氢喹啉-3-羧酸

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In the present study, a series of 1-cyclopropyl-7[4-(2,6-dimethylpyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid, 1-cyclopropyl-7[4-(2,6-dimethoxypyrimidin-2-yl-diazenyl)-piperzin-l-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid and their dione derivatives have been synthesized in moderate yield. The newly synthesized compounds 5a-j have been characterized by IR, H-1 NMR and elemental analysis. These compounds have been evaluated for their in vitro antibacterial activity against some gram-positive and gram-negative bacteria using conventional agar-dilution method. The antibacterial data of the newly synthesized compounds indicate that some of them showed better antibacterial activity as compared to their reference drug ciprofloxacin.

机译：在本研究中，一系列1-环丙基-7 [4-（2,6-二甲基嘧啶-2-基二亚苯基）-3-氟-4-氧代-1,4-二氢喹啉酮 -3-羧酸，1-环丙基-7 [4-（2,6-二甲氧基嘧啶-2-基二亚苯基）-6-氟-4-氧代-1,4-二氢喹啉-3 - 羧酸和它们的脱硫衍生物已以中等产率合成。新合成的化合物5A-J已经表征了IR，H-1 NMR和元素分析。已经使用常规琼脂稀释方法评估这些化合物的体外抗菌活性，其针对一些革兰氏阳性和革兰氏阴性细菌。新合成化合物的抗菌数据表明，与其参考药物Ciprofloxacin相比，其中一些术语显示出更好的抗菌活性。

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《Indian Journal of Chemistry, Section B. Organic Including Medicinal》 |2018年第8期|共5页
作者
Yadav Radeep; Hada Sonal; Yadav Dinesh Kumar; Kumari Neetu;
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Univ Rajasthan Dept Chem Jaipur 302004 Rajasthan India;

Mohanlal Sukhadia Univ Dept Chem Udaipur 313001 India;

Mohanlal Sukhadia Univ Dept Chem Udaipur 313001 India;

Mohanlal Sukhadia Univ Dept Chem Udaipur 313001 India;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Dimethylpyrimidine; dimethoxypyrimidine; 1; 3-dione derivatives; ciprofloxacin; antibacterial activity;

机译：二甲基嘧啶;二甲氧基嘧啶;1;3-二酮衍生物;环丙沙星;抗菌活性;

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1. Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7-[4-(2,6-dimethyl/dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid [J] . Yadav Radeep, Hada Sonal, Yadav Dinesh Kumar, Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2018,第8期

机译：1-环丙基-7- [4-（2,6-二甲基/二甲氧基嘧啶-2-基二亚苄酯-2-基二甲酰基）-3-氟-4-4-氟-4-的合成和1,3-二酮衍生物的合成和抗菌活性。-6-氟-4- Oxo-1,4-二氢喹啉-3-羧酸
2. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1,3-DIONE DERIVATIVES OF 1-CYCLOPROPYL-7-[4-(2,6-DIMETHYL/ DIMETHOXY-PYRIMIDIN-2-YL-DIAZENYL) PIPERZIN-1-YL]-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID [J] . PRADEEP YADAV, REENKOO SINGHAL, SANDEEP SINGH, International Journal of Pharmacy and Pharmaceutical Sciences . 2013,第4期

机译：1-环丙基-7- [4-（2,6-二甲基/二甲氧基-吡唑啉-2-基-二氮杂）哌啶-1-基] -6-氟4的1,3-二酮衍生物的合成及抗菌活性-OXO-1,4-二氢喹啉-3-羧酸
3. Synthesis and antibacterial activity of a new derivative of the meldrun acid: 2,2-dimethyl-5-(4H-1,2,4-triazol-4-ylaminomethylene)-1,3-dioxane-4,6-dione (C₉H₁₀N₄O₄) [J] . Sampaio GMM, Teixeira AMR, Coutinho HDM, EXCLI Journal . 2014,第1期

机译：麦德龙酸新衍生物的合成及抗菌活性：2,2-二甲基-5-（4H-1,2,4-三唑-4-基氨基亚甲基）-1,3-二恶烷-4,6-二酮（C _{9 H _{10 N _{4 O _{4 ）}}}}
4. Synthesis, characterization and luminescence of europium, terbium complexes of 1,1'-(pyridin-2,6-diyl)bis-3-p-tolylpropane-1,3-dione [C] . Jinliang Zhu, Shengli Liu, Liangcai Yu, International conference on advanced materials . 2011

机译：合成，表征和发光的铕，铽络合物1,1' - （吡啶-2,6-二基）双-3-甲苯基丙烷-1,3-二酮
5. I. A1,3- strain enabled retention of chirality during Bis-cyclization of β-ketoamides: Asymmetric synthesis and bioactivity of salinosporamide a and derivatives II. Optimization of an Organic syntheses procedure: asymmetric nucleophile-catalyzed aldol-lactonization with aldehyde acids [D] . Nguyen, Henry 2010

机译：I. A1,3-菌株能够在β-酮基酰胺的双环化过程中保留手性：salinosporamide a和衍生物II的不对称合成和生物活性。有机合成程序的优化：醛酸不对称亲核催化醛醇内酯化
6. Synthesis and antibacterial activity of a new derivative of the Meldrun acid: 22-dimethyl-5-(4H-124-triazol-4-ylaminomethylene)-13-dioxane-46-dione (C9H10N4O4) [O] . Gillena M. M. Sampaio, Alexandre M. R. Teixeira, Henrique D. M. Coutinho, 2014

机译：Meldrun酸的新衍生物的合成及其抗菌活性：22-二甲基-5-（4H-124-三唑-4-基氨基亚甲基）-13-二恶烷-46-二酮（C9H10N4O4 ）
7. Synthesis and antibacterial activity of a new derivative of the meldrun acid: 2,2-dimethyl-5-(4H-1,2,4-triazol-4-ylaminomethylene)-1,3-dioxane-4,6-dione (C9H10N4O4) [O] . Sampaio Gillena M. M., Teixeira Alexandre M. R., Coutinho Henrique D. M., 2014

机译：麦德龙酸新衍生物的合成及抗菌活性：2,2-二甲基-5-（4H-1,2,4-三唑-4-基氨基亚甲基）-1,3-二恶烷-4,6-二酮（C9H10N4O4 ）

Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7-[4-(2,6-dimethyl/dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid

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