NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY

D. Sai Priya; Kini S. G; Bhatt V. G; Rathi E; Muralidharan A

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NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY

机译：新型Schiff替代2-氨基苯并噻唑的基础：设计，合成和抗微生物活性

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Novel Schiff's bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was performed by agar diffusion method against a panel of bacterial strains such as S. aureus, B. subtilis (Gram-positive bacteria), E. coli, P. aeruginosa (Gram-negative bacteria) and fungal strains such as C. albicans and A. niger. Compound S13 and S17 had shown potent antifungal activity against C. albicans and A. niger respectively among the novel Schiff's base compounds when compared to standard, and S13 compound had only shown moderate antibacterial activity against S. aureus amongst all. Molecular docking study was carried out against C. albicans DHFR (Dihydrofolate Reductase) domain to confirm their activity.

机译：通过单步工艺通过2-氨基苯并噻唑和取代的苯甲醛的简单缩合来合成新的Schiff的碱基轴承二氨基苯并噻唑，并通过FTIR，1HNMR和质谱数据进行进一步表征。通过琼脂扩散法对化合物的抗微生物活性对细菌菌株如S.UUREUS，B.枯草芽孢杆菌（革氏阳性细菌），大肠杆菌，P.铜绿假单胞菌（革兰氏阴性细菌）和真菌菌株（如 C.老年人和A.尼日尔。与标准相比，化合物S13和S17分别对C.醛糖醛植物和A.尼日尔的有效的抗真菌活性分别示出了蛋白化合物和A.尼日尔。S13化合物只显示了所有人中的抗菌活性的中度抗菌活性。分子对接研究对C. albicans DHFR（二羟氢醇还原酶）结构域进行，以确认其活动。

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来源
《Indian drugs》 |2018年第4期|共9页
作者
D. Sai Priya; Kini S. G; Bhatt V. G; Rathi E; Muralidharan A;
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作者单位

Department of Pharmaceutical Chemistry Manipal College of Pharmaceutical Sciences Manipal;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
2-amino benzothiazoles; Schiff's base; Synthesis; in vitro antimicrobial activity;

机译：2-氨基苯并噻唑;Schiff的基础;合成;体外抗微生物活性;

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NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY

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