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首页> 外文期刊>Industrial Crops and Products >Abutilon theophrasti medic. Episperms as a total flavonoids fraction for pharmaceutical applications: In vitro antioxidant, antibacterial, anti-inflammatory activities, extraction technology and HPLC-MS profiles
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Abutilon theophrasti medic. Episperms as a total flavonoids fraction for pharmaceutical applications: In vitro antioxidant, antibacterial, anti-inflammatory activities, extraction technology and HPLC-MS profiles

机译：Abutilon Theophrasti Medic。 作为药物应用的总黄酮级分数：体外抗氧化剂，抗菌，抗炎活性，提取技术和HPLC-MS型材

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摘要

Abutilon theophrasti Medic. is widely distributed around the world, and the episperms part is rich in phenols and flavonoids compounds. The current study focused on the extraction technology, components analysis, in vitro antioxidant, antibacterial, and anti-inflammatory activities of total flavonoids from Abutilon theophrasti Medic. episperms. The extraction process of total flavonoids fraction was optimized by response surface method, and the antioxidant, antibacterial, and anti-inflammatory activities were evaluated with the assay of radical scavenging activity and reducing power, micro-dilution broth method, and lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model, respectively. The maximum extraction yield was achieved with concentration of ethanol solution 10%, ratio of solvent to material 30:1 ml/g, and ultrasonic extraction time 29.52 min. Moreover, seven compositions from total flavonoids fraction were detected separately, and four compounds were identified by high performance liquid chromatography-diode array detector-electrospray ionization-mass spectra(n). In addition, total flavonoids fraction from Abutilon theophrasti Medic. episperms exhibited a better antioxidant activity demonstrated by ferric ion reducing antioxidant power, 2, 2' - azino - bis (3-ethylbenzothiazoline -6-sulfonic acid diammonium salt, and 2, 2 -diphenyl -1-picrylhydrazyl radicals scavenging ability, and antibacterial against Escherichia coli, Salmonella, Staphyloccocus aureus, and Streptococcus, and antiinflammatory activities in lipopolysaccharide induced RAW 264.7 cells. In a word, the present findings suggest that the total flavonoids fraction from Abutilon theophrasti Medic. episperms was a very interesting candidate for the research and development of natural and healthy antioxidant, antibacterial, and anti-inflammatory agent for food, pharmaceutical, and medicine industries.
机译：Abutilon Theophrasti Medic。广泛分布在世界各地，术术部件富含酚类和黄酮类化合物。目前的研究重点是来自Abutilon Theophrasti Medic的提取技术，组分分析，体外抗氧化剂，抗菌和抗炎活性。 episperms。通过响应表面法优化总黄酮级分的提取过程，并通过测定的自由基清除活性和降低功率，微量稀释肉汤法和脂多糖诱导小鼠单核巨噬细胞进行抗氧化剂，抗菌和抗炎活性进行评估白血病细胞原料264.7模型。通过浓度的乙醇溶液10％，溶剂与材料的比例实现最大萃取产率30：1mL / g，超声提取时间29.52分钟。此外，单独检测来自总黄酮级分的七种组合物，并通过高效液相色谱 - 二极管阵列检测器 - 电喷雾电离质谱（N）鉴定四种化合物。此外，Abutilon Theophrasti Medic的总类黄酮部分。 episperms表现出通过铁离子还原抗氧化能力，2,2' - 氮杂基团（3-乙基苯并噻唑啉-6-磺酸二羟基盐，2,2-二苯基-1-富铬酰基自由基清除能力，以及抗菌的抗氧化活性对抗大肠杆菌，沙门氏菌，金黄色葡萄球菌和链球菌，以及脂多糖的抗炎活性诱导原料264.7细胞。总之，本研究结果表明，阿比尔顿Theophrasti MENCE的总黄酮级分数。episperms是研究的非常有趣的候选者食品，制药和医药产业的天然健康抗氧化剂，抗菌和抗炎剂的发展。

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  • 来源
    《Industrial Crops and Products》 |2019年第2019期|共7页
  • 作者

    Tian Chunlian; Wang Hong; Guo Yuru; Qiu Peng; Cui Cancan; Liu Mingchun;

  • 作者单位

    Shenyang Agr Univ Coll Anim Sci &

    Vet Med Key Lab Zoonosis Liaoning Prov 120 Dongling Rd Shenhe Dist Shenyang 110866 Liaoning Peoples R China;

    Shenyang Agr Univ Coll Anim Sci &

    Vet Med Key Lab Zoonosis Liaoning Prov 120 Dongling Rd Shenhe Dist Shenyang 110866 Liaoning Peoples R China;

    Shenyang Agr Univ Coll Anim Sci &

    Vet Med Key Lab Zoonosis Liaoning Prov 120 Dongling Rd Shenhe Dist Shenyang 110866 Liaoning Peoples R China;

    Shenyang Agr Univ Coll Anim Sci &

    Vet Med Key Lab Zoonosis Liaoning Prov 120 Dongling Rd Shenhe Dist Shenyang 110866 Liaoning Peoples R China;

    Shenyang Agr Univ Coll Anim Sci &

    Vet Med Key Lab Zoonosis Liaoning Prov 120 Dongling Rd Shenhe Dist Shenyang 110866 Liaoning Peoples R China;

    Shenyang Agr Univ Coll Anim Sci &

    Vet Med Key Lab Zoonosis Liaoning Prov 120 Dongling Rd Shenhe Dist Shenyang 110866 Liaoning Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 农作物;
  • 关键词

    Abutilon theophrasti medic. Episperms; Total flavonoids; Composition analysis; Antioxidant activity; Antibacterial activity; Anti-inflammatory activity;

    机译：Abutilon Theophrasti Medic。 episperms;总黄酮;成分分析;抗氧化活性;抗菌活性;抗炎活动;

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