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首页> 外文期刊>Advances in clinical chemistry >Effect of caloric restriction on oxidative markers.
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Effect of caloric restriction on oxidative markers.

机译：热量限制对氧化标记的影响。

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Caloric restriction is associated with a decreased level of oxidative stress. Reactive oxygen species (ROS) generated predominantly in mitochondria are attenuated by decreased caloric intake. On the other hand, antioxidative mechanisms are frequently accelerated by increased gene expression or activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, paraoxonase, etc.). Measurement of different oxidative stress markers in relationship to caloric restriction is therefore important in experimental as well as clinical studies. Estimation of ROS in tissues and fluids is typically performed by measurement of oxidant products (i.e., malondialdehyde, F-2-isoprostanes, nitrotyrosine) and markers of antioxidant system (enzymes, glutathione, alpha-tocopherol, ascorbic acid, ubichinone, etc.). Because both components are critical to objectively understand the oxidative stress state, tangible biochemical data is required in order to comprehensively elucidate pathobiologic mechanisms and potential therapeutic regimes involving lifestyle changes that include caloric restriction or moderate physical activity.
机译：热量限制与氧化应激水平降低有关。线粒体中主要产生的活性氧（ROS）会因热量摄入减少而减弱。另一方面，抗氧化机制通常通过增加基因表达或抗氧化酶（超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶，对氧磷酶等）的活性而加速。因此，测量与热量限制有关的不同氧化应激标志物在实验和临床研究中都很重要。通常通过测量氧化剂产物（即丙二醛，F-2-异前列腺素，硝化酪氨酸）和抗氧化剂系统的标志物（酶，谷胱甘肽，α-生育酚，抗坏血酸，泛醌等）​​来估算组织和体液中的ROS。 。由于这两个成分对于客观地了解氧化应激状态都至关重要，因此需要有形的生化数据，以全面阐明病理生活方式和潜在的治疗方案，这些生活方式涉及包括热量限制或适度体育锻炼在内的生活方式的改变。

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