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首页> 外文期刊>International immunopharmacology >Ribonuclease attenuates acute intestinal injury induced by intestinal ischemia reperfusion in mice
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Ribonuclease attenuates acute intestinal injury induced by intestinal ischemia reperfusion in mice

机译：核糖核酸酶通过小鼠肠缺血再灌注诱导急性肠道损伤

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摘要

Ribonuclease (RNase) reportedly exerts organ-protective effects in several pathological conditions, including ischemia reperfusion (I/R), but whether it can exhibit protective effect on intestinal I/R injury and potential mechanisms remain unknown. The present study was aimed to evaluate the effects of RNase on intestinal I/R injury and explore the underlying mechanisms. Thirty-two wild-type C57BL/6J adult male mice were evenly divided into a sham group, a sham + RNase group, an I/R group and an I/R + RNase group. Intestinal I/R was produced by clamping the superior mesenteric artery for 1 h followed by reperfusion for 2 h. All mice were treated with 3 doses of RNase or the same dosage of normal saline at different points. It was found that intestinal I/R caused significant intestinal injury and an increase in levels of extracellular RNAs (exRNAs). Treatment with RNase significantly reduced the inflammatory cytokine production, inhibited intestinal apoptosis and down-regulated the expression of toll like receptor 3 in intestinal tissues. In conclusion, increased exRNAs may contribute to intestinal I/R injury in adult mice, and RNase treatment during perioperative window is effective for attenuating intestinal I/R injury.
机译：Ribonuclease（RNase）据报道，在几种病理条件下施加器官保护作用，包括缺血再灌注（I / R），但它是否可以对肠道I / R损伤表现出保护作用，并且潜在机制仍然未知。本研究旨在评估RNase对肠I / R损伤的影响，探讨潜在机制。将三十二型C57BL / 6J成年小鼠均匀分为假组，假+ RNase组，I / R组和I / R + RNase组。通过夹住优质肠系膜动脉1小时，然后再灌注2小时来制备肠道I / R。将所有小鼠用3剂RNase或相同的生理盐水处理，在不同点处理。发现肠道I / R引起了显着的肠损伤和细胞外RNA（EXRNA）水平的增加。用RNase治疗显着降低了炎症细胞因子产生，抑制肠道凋亡，下调了肠组织中的受体3的损伤表达。总之，增加的EXRNA可能有助于成年小鼠的肠I / R损伤，并且围手术期间的RNase治疗对于减少肠I / R损伤是有效的。

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