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首页> 外文期刊>International immunopharmacology >The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: A 3-month follow-up study
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The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: A 3-month follow-up study

机译：维生素E对产前和早期产前乙醇治疗诱导的大鼠心脏异常的保护作用：3个月的后续研究

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Ethanol consumption during pregnancy is associated with fetal heart malformation. However, the underlying mechanism of prenatal ethanol exposure causing heart malfunction is not well known. The current study examined the effect of prenatal and early postnatal ethanol consumption on heart abnormality resulting from oxidative and inflammatory stress. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rats' heart tissue. Pregnant Wistar rats received ethanol with/without vitamin E from the seventh day of gestation (GD7) throughout lactation. The proliferation in heart muscle cells and coronary smooth muscle cells, protein carbonyl, IL-6, TNF-alpha, homocysteine levels, also lipid profile in heart and plasma of male pups were measured at the end of lactation (PN 21) and 90 days after birth (PN 90). The results indicated proliferation of heart muscle and coronary smooth muscle cells along with heart structural alteration, protein oxidation, lipid peroxidation, inflammatory reaction, and hyperhomocysteinemia in offspring after 21 and 90 days of birth compared with the controls. Vitamin E treatment significantly decreased cell proliferation and heart structural alteration, compared with the group treated by ethanol alone. Furthermore, it reduced the elevation of protein carbonyl, lipid peroxidation, and increased inflammatory proteins to levels as those of the controls. These findings strongly support the idea that ethanol intake by dams during pregnancy and early postnatal days induces heart abnormality mediated by oxidative stress and inflammatory reactions, and that these effects can be alleviated by using vitamin E as an antioxidant and anti-inflammatory molecule. (C) 2015 Elsevier B.V. All rights reserved.
机译：妊娠期间的乙醇消费与胎儿畸形有关。然而，产前乙醇暴露导致心脏发生故障的潜在机制是众所周知的。目前的研究检测了氧化和炎症应激导致的产前和早期后乙醇消耗对心脏异常的影响。它还旨在了解维生素E是否抑制乙醇在大鼠心脏组织中诱导的异常。在整个泌乳过程中，怀孕的Wistar大鼠从妊娠（GD7）的第七天获得乙醇/没有维生素E.在哺乳期结束（PN 21）和90天，测量心肌细胞和冠状动脉细胞和冠状动脉细胞，蛋白质羰基，IL-6，TNF-α，同型胰岛素水平的脂质曲线和雄性幼崽的血脂曲线出生后（PN 90）。结果表明，与对照组21至90天后，心脏结构改变，蛋白质氧化，脂质过氧化，炎症反应，蛋白质氧化，脂质过氧化，炎症反应和高流囊血症。与单独的乙醇处理的组相比，维生素E治疗显着降低了细胞增殖和心脏结构改变。此外，它降低了蛋白质羰基，脂质过氧化和增加的炎症蛋白的升高，作为对照的水平。这些发现强烈支持乙酰醇在怀孕期间和早期的后期摄入乙醇诱导心脏异常诱导被氧化应激和炎症反应介导的心脏异常，并且可以通过使用维生素E作为抗氧化剂和抗炎分子来缓解这些效果。 （c）2015 Elsevier B.v.保留所有权利。

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