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首页> 外文期刊>International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience >Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm
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Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm

机译：新生儿全身炎症和低分的风险，在10年龄出生的儿童中10年的阅读和数学成果措施

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Background: Difficulties with reading and math occur more commonly among children born extremely preterm than among children born at term. Reasons for this are unclear.& para;& para;Methods: We measured the concentrations of 27 inflammatory-related and neurotrophic/angiogenic proteins (angio-neurotrophic proteins) in multiple blood specimens collected a week apart during the first postnatal month from 660 children born before the 28th week of gestation who at age 10 years had an IQ = 70 and a Wechsler Individual Achievement Test 3rd edition (WIAT-III) assessment. We identified four groups of children, those who had a Z-score = -1 on the Word Reading assessment only, on the Numerical Operations assessment only, on both of these assessments, and on neither, which served as the referent group. We then modeled the risk of each learning limitation associated with a top quartile concentration of each protein, and with high and lower concentrations of multiple proteins.& para;& para;Results: The protein profile of low reading scores was confined to the third and fourth postnatal weeks when increased risks were associated with high concentrations of IL-8 and ICAM-1 in the presence of low concentrations of angio-neurotrophic proteins. The profile of low math scores was very similar, except it did not include ICAM-1. In contrast, the profile of low scores on both assessments was present in each of the first four postnatal weeks. The increased risks associated with high concentrations of TNF-alpha in the first two weeks and of IL-8 and ICAM-1 in the next two weeks were modulated down by high concentrations of angio-neurotrophic proteins.& para;& para;Conclusions: High concentrations of angio-neurotrophic proteins appear to reduce/moderate the risk of each learning limitation associated with systemic inflammation. The three categories of limitations have protein profiles with some similarities, and yet some differences, too.
机译：背景：阅读和数学的困难更常见于出生的早产比在学期出生的儿童中的困难。对此的原因尚不清楚。＆para;＆para;方法：我们测量了在660名后期第一次出生的第一个后期收集的多个血液标本中血液标本中的27个炎症相关和神经营养蛋白质蛋白的浓度在妊娠的第28周之前出生于10岁的妊娠，智商= 70 = 70和威斯勒个人成就测试第3版（WIAT-III）评估。我们确定了四组儿童，那些只有一个z-score的人甚至只有在阅读评估中，只有在这些评估中的数值操作评估上，既不是指代参考组。然后，我们建模了与每种蛋白质的顶部四分位数浓度相关的每个学习限制的风险，以及高浓度的多种蛋白质。＆para;＆para;结果：低读数分数的蛋白质概况被限制在第三个和第三个在存在低浓度的血管神经营养蛋白的情况下，第四个后几周与高浓度的IL-8和ICAM-1相关。低数学分数的简介非常相似，除了它不包括ICAM-1。相比之下，在前四个后几周的每一个中存在两种评估的低分性的轮廓。通过高浓度的血管神经营养蛋白，调节与前两周和IL-8和ICAM-1高浓度的TNF-α相关的风险增加。＆段;＆段;结论：高浓度的血管神经营养蛋白似乎减少/中度与系统性炎症相关的每个学习限制的风险。三类限制具有蛋白质谱，具有一些相似之处，但也有一些差异。

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