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首页> 外文期刊>International journal of immunogenetics >IFN‐γ IFN‐γ +874T/A polymorphism increases susceptibility to post‐traumatic osteomyelitis
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IFN‐γ IFN‐γ +874T/A polymorphism increases susceptibility to post‐traumatic osteomyelitis

机译：IFN-γIFN-γ+ 874t / a多态性会增加对后松后骨髓炎的敏感性

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摘要

Abstract Immunological inflammatory reaction is one of the key links in the occurrence and development of post‐traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN‐γ and bone remodelling cells. However, potential association of IFN‐γ gene polymorphism with susceptibility to post‐traumatic osteomyelitis remains unclear. This study aimed to investigate the potential link between IFN‐γ +874T/A polymorphism and risk of developing post‐traumatic osteomyelitis. A total of 189 patients with post‐traumatic osteomyelitis and 200 healthy controls were enrolled for genotyping using the SNaPshot genotyping method. Statistically significant associations were found between the gene polymorphism and the risk of post‐traumatic osteomyelitis by dominant model (AA?+?AT vs. TT, OR?=?1.820, p ?=?.017) and heterozygous model (AT vs. TT, OR?=?1.781, p ?=?.029). Moreover, the frequency of mutant allele A was significantly higher in the patients than that in the healthy controls (15.07% vs. 9.25%, OR?=?1.742, p ?=?.013). IFN‐γ +874T/A polymorphism may contribute to the increased susceptibility to post‐traumatic osteomyelitis.
机译：摘要免疫炎症反应是微生物侵袭后创伤后骨髓炎发生和发展的关键环节之一。日益增长的证据表明IFN-γ和骨改造细胞之间的复杂相互作用。然而，IFN-γ基因多态性与易受创伤后骨髓炎的潜在关联仍然不清楚。该研究旨在研究IFN-γ+ 874T /型多态性与研发后骨髓炎的潜在联系。使用快照基因分型方法，共注册了189名患有创伤后骨髓炎和200个健康对照的患者。在基因多态性和通过优势模型的基因多态性和创伤后骨髓炎的风险之间发现了统计性显着的关联（AA？+Δ= TT，或？=？1.820，P？=β.017）和杂合模型（在Vs. tt，或？=？1.781，p？= 029）。此外，患者突变等位基因A的频率显着高于健康对照（15.07％与9.25％，或α1.742，p？= 013）。 IFN-γ+ 874t / a多态性可能有助于增加对后创伤后骨髓炎的易感性。

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