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首页> 外文期刊>International journal of immunogenetics >Influence of NKG2C gene deletion and CCR5Δ32 in Pre‐eclampsia—Approaching the effect of innate immune gene variants in pregnancy
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Influence of NKG2C gene deletion and CCR5Δ32 in Pre‐eclampsia—Approaching the effect of innate immune gene variants in pregnancy

机译：NKG2C基因缺失和CCR5δ32在预痫预处理妊娠期妊娠期异常免疫基因变体的影响

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Abstract Pre‐eclampsia (PE) is a hypertensive disorder that affects an important number of pregnant women worldwide. The exact causes of PE remain poorly understood. However, inflammation and deregulation of innate immune cells, such as natural killer (NK) cells, contribute to PE pathogenesis. Besides, the mother's genetic background also impacts on PE susceptibility. Thus, genetic variants that potentially modify the behaviour of inflammatory cells may help us to understand the causes of PE. Variants of genes encoding NKG2C (expressed in NK cells) and C–C chemokine receptor type 5 (CCR5) (expressed mainly in leucocytes) are important targets in the study of gestational disorders. In this context, we evaluated the impact of both NKGC2 gene deletion and CCR5Δ32 gene variant on PE susceptibility in a population sample from central‐southeast Brazil composed by 369 women (156 with PE and 213 healthy pregnant women). No statistically significant association between the NKG2C gene deletion and susceptibility to PE was observed. However, taking into consideration the important role of NK cells in pregnancy, the influence of NKG2C gene deletion on PE pathogenesis should not be ruled out and deserves further studies in populations with different genetic/ethnic backgrounds. In addition, our results regarding CCR5Δ32 corroborate previous data from our group approaching a distinct cohort and reinforce CCR5Δ32 as a protective factor against PE development ( p ??0.05).
机译：摘要预普拉明血症（PE）是一种影响全世界重要孕妇的高血压障碍。 PE的确切原因仍然明白很差。然而，天生免疫细胞的炎症和放松管制，例如天然杀伤（NK）细胞，有助于PE发病机制。此外，母亲的遗传背景也对PE易感性产生影响。因此，可能改变炎症细胞行为的遗传变异可以帮助我们理解PE的原因。编码NKG2C的基因的变体（在NK细胞中表达）和C-C趋化因子受体类型5（CCR5）（主要在白细胞表达）是妊娠期疾病研究中的重要靶标。在这种情况下，我们评估了NKGC2基因缺失和CCR5Δ32基因变异对由369名女性中央 - 东南巴西的人口样品中的PE易感性的影响（156名与PE和213名健康孕妇）。观察到NKG2C基因缺失与PE易感性之间没有统计学上显着的关联。然而，考虑NK细胞在怀孕中的重要作用，不应排除NKG2C基因缺失对PE发病机制的影响，并且应该进一步研究具有不同遗传/民族背景的群体。此外，我们的研究结果是CCR5Δ32证实了来自我们的小组的先前数据，接近不同的队列和加强CCR5Δ32作为针对PE显影的保护因素（P？＆ 0.05）。

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