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首页> 外文期刊>International journal of immunogenetics >Association of cytotoxic T‐lymphocyte associated protein 4 gene polymorphisms with the risk and prognosis of oesophageal cancer in a high‐incidence region from northern China
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Association of cytotoxic T‐lymphocyte associated protein 4 gene polymorphisms with the risk and prognosis of oesophageal cancer in a high‐incidence region from northern China

机译：来自北方北方高发症地区食管癌风险和预后的细胞毒性T淋巴细胞相关蛋白4基因多态性

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Abstract The most important anti‐tumour immune response is mediated by T lymphocytes. Cytotoxic T lymphocyte‐associated protein 4 (CTLA4) plays a critical role in the immune surveillance against tumours as an inhibitory immune checkpoint molecule of T‐cell activation. This study was designed to explore the association of CTLA4 polymorphisms with the susceptibility to oesophageal squamous cell carcinoma (ESCC) and prognosis of patients with ESCC in a high‐incidence population from northern China. CTLA4 rs5742909 C/T and rs231775 G/A single nucleotide polymorphisms (SNPs) were genotyped using polymerase chain reaction–ligase detection reaction (PCR‐LDR) method in 577 ESCC patients and 580 controls. Upper gastrointestinal cancer family history increased the risk of ESCC (the sex‐, age‐ and smoking status‐adjusted OR?=?1.383, 95%CI?=?1.094–1.749). The genotype frequencies of these two SNPs in the patients with ESCC were similar to that in the controls. Survival analyses were conducted in 204 patients with ESCC with five‐year survival information. The mean survival time of ESCC patients with rs231775 SNP A/A genotype in age over 60?years group was 23.2?months, significantly shorter than that of those with G/G genotype (47.3?months). The A/A genotype was associated with increased death risk of patients with ESCC older than 60?years (adjusted HR?=?4.544, 95%CI?=?1.913–10.790). CTLA4 rs231775 SNP might be used as genetic marker of worse prognosis for patients with ESCC over 60?years in a high‐incidence population from northern China.
机译：摘要最重要的抗肿瘤免疫反应是由T淋巴细胞介导的。细胞毒性T淋巴细胞相关蛋白4（CTLA4）在免疫监测中起重要作用，作为T细胞活化的抑制性免疫检查点分子。本研究旨在探讨CTLA4多态性与北方北方高发病率群体患者的患者鳞状细胞癌（ESCC）和预后的易感性。 CTLA4 RS5742909 C / T和RS231775 G / A单核苷酸多态性（SNP）在577名ESCC患者中使用聚合酶链反应 - 连接酶检测反应（PCR-LDR）方法和580个对照组进行基因分型。上胃肠癌家族史增加了ESCC的风险（性别，年龄和吸烟状态调整或？=？1.383,95％CI？=？1.094-1.749）。 ESCC患者中这两个SNP的基因型频率与对照中的患者类似。生存分析在204例ESCC患者中进行了五年的生存信息。 ESCC患者的平均存活时间超过60岁以上患者的A / A基因型为23.2岁，比G / G基因型（47.3？月份）显着短。 A / A基因型与ESCC患者的死亡风险增加到60岁以下的患者（调整后的HR？= 4.544,95％CI？=？1.913-10.790）。 CTLA4 RS231775 SNP可能被用作ESCC患者预后的遗传标记超过60岁以上的患者，从中国北方的高发病率群体。

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