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首页> 外文期刊>International journal of immunogenetics >MHC class I polymorphic Alu Alu insertion (POALIN) allele and haplotype frequencies in the Arabs of the United Arab Emirates and other world populations
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MHC class I polymorphic Alu Alu insertion (POALIN) allele and haplotype frequencies in the Arabs of the United Arab Emirates and other world populations

机译：MHC I类多晶型ALU ALU插入（POALIN）等位基因和单倍型频率在阿拉伯联合酋长国和其他世界人口的阿拉伯人

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Abstract Polymorphic Alu insertions (POALINs) are found throughout the human genome and have been used in various studies to infer geographic origin of human populations. The main aim of this study was to determine the allele and haplotype frequencies of five POALINs, AluHF , AluHG , AluHJ , AluTF and AluMICB , within the major histocompatibility complex (MHC) class I region of 95 UAE Arabs, and correlate their frequencies to those of the HLA‐A , HLA‐C and HLA‐B class I allele lineages. Evolutionary relationships between the POALINs of the Arabs and those previously studied in populations of African, Asian and European descent were compared. At each of the five Alu loci ( AluHF , AluHG , AluHJ , AluTF and AluMICB ), Alu insertion was designated as Alu(locus)*02 and absence was Alu(locus)*01 . The AluHG insertion ( AluHG*02 ) had the highest frequency (0.332), followed by AluHF*02 (0.300), AluHJ*02 (0.263), AluMICB*02 (0.111) and AluTF*02 (0.058). Of the 270 Alu‐HLA haplotypes pairs in the UAE Arabs, 110 had no Alu insertion, and 54 had an Alu insertion at 50% per haplotype. An Alu insertion 75% per haplotype was found between AluMICB*02 and HLA‐B*14, HLA‐B*22, HLA‐B*44, HLA‐B*55 , HLA‐B*57 and HLA‐B*73 , and with HLA‐C*01 and HLA‐C*18 ; AluHJ*02 with HLA‐A*01 , HLA ‐A*19, HLA‐A*24 and HLA‐A*32 ; AluHG*02 with HLA‐A*02 and HLA‐B*18 ; and AluHF*02 with HLA‐A*10 . The genotyped allele and haplotype frequencies of the MHC POALINs in UAE Arabs were compared with the results of 30 previously published Asian, European, American and African populations. Phylogenetic and multidimensional scaling (MDS) analysis of the relative MHC POALINs allele and haplotype frequencies revealed that the UAE Arabs have a similar lineage to Caucasians and the most distant genetic relationship to the Waorani native American population of Ecuador. The structure of both the phylogenetic tree and the MDS analysis supports the Out of Africa theory of human evolution. The nature of the clusters suggests the Arabian Middle East represents a crossroads from which human populations migrated towards Asia in the east and Europe to the north‐west.
机译：摘要在整个人类基因组中发现了多态Alu插入（POALINS），并且已用于各种研究中以推断人口的地理来源。本研究的主要目的是确定五个花盆，aluHF，Aluhg，Aluhj，Alutf和AlumicB的等位基因和单倍型频率，在95乌拉阿阿拉伯人的主要组织相容综合体（MHC）I级地区内，并将它们的频率与那些相提并论HLA-A，HLA-C和HLA-B类I等位基因谱系。比较了阿拉伯人诗歌与非洲人，亚洲和欧洲血统研究中的诗歌族的进化关系。在五种Alu基因座（AluHF，Aluhg，Aluhj，Alutf和AlumicB）中的每一个中，Alu插入被指定为Alu（基因座）* 02并且不存在是Alu（基因座）* 01。 Aluhg插入（Aluhg * 02）具有最高的频率（0.332），然后是aluHF * 02（0.300），AluHJ * 02（0.263），AlumicB * 02（0.111）和Alutf * 02（0.058）。在阿联酋阿拉伯阿拉伯阿拉伯阿拉伯人的270份Alu-HLA单倍型，110没有Alu插入，54个alu插入＆每单倍型50％。在AlumicB * 02和HLA-B * 14，HLA-B * 22，HLA-B * 44，HLA-B * 55，HLA-B * 57和HLA-B之间发现了每单倍型，每单倍型75％。 73，以及HLA-C * 01和HLA-C * 18; Aluhj * 02带HLA-A * 01，HLA -A * 19，HLA-A * 24和HLA-A * 32; Aluhg * 02与HLA-A * 02和HLA-B * 18;和HLA-A * 10的Aluhf * 02。与阿拉伯联合酋长国阿拉伯人的基因分型等位基因和单倍型频率与30以前公布的亚洲，欧洲，美国和非洲人口的结果进行了比较。对相对MHC POALINS等级和单倍型频率的系统发育和多维缩放（MDS）分析表明，阿联酋阿拉伯人对高加索人的血统和最遥远的遗传关系与Waorani美洲原住民厄瓜多尔人口相似。系统发育树和MDS分析的结构支持非洲人类演变理论。集群的性质表明，阿拉伯中东代表了一个十字路口，从中迁移到东北部和欧洲的人口迁移到西北部。

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