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首页> 外文期刊>International journal of immunogenetics >Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival
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Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival

机译：重新移植候选者IgA同种型的抗HLA丙基部分第二部分：与移植物存活的相关性

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摘要

We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold etal., ). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (TTD 77months) compared to patients carrying either anti-HLA IgG or IgA (TTD 102 and 94months, respectively). In addition, donor specificity of anti-HLA IgA had a significant negative impact on graft survival (TTD 74months) in our study. Taken together, our data strongly indicate that presence of anti-HLA IgA, in particular in conjunction with anti-HLA-IgG, in sera of kidney re-tx patients is associated with negative transplantation outcome.
机译：我们之前报道了在固体器官再移植（RE-TX）候选的血清中IgA同种型（抗HLA IgA）的抗HLA抗HLA AlloAlibodies（Re-TX）候选者（Arnold Etal。）。专注于肾脏重新TX患者，我们现在通过检查抗HLA IGA的存在和供体特异性对移植物存活的影响来扩展了我们的早期发现。我们观察到抗HLA IGA和抗HLA IgG的27％的694个肾脏re-TX患者的27％频繁同时。该亚组显着降低接枝存活，从而通过在移植（TTD 77MONTH）与患有抗HLA IgG或IgA（TTD 102和94MONTH）的患者进行移植（TTD 77MONTH）后的第一次透析的时间来证明。此外，抗HLA IGA的供体特异性对我们研究中的接枝存活（TTD 74个月）产生了显着的负面影响。我们的数据一起表明，抗HLA IgA的存在，特别是与抗HLA-IgG一起，在肾脏再革X患者的血清中，与阴性移植结果相关。

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    Arnold M. -L.; Bach C.; Heinemann F. M.; Horn P. A.; Ziemann M.; Lachmann N.; Muehlbacher A.; Dick A.; Ender A.; Thammanichanond D.; Schaub S.; Honger G.; Fischer G. F.; Mytilineos J.; Hallensleben M.; Hitzler W. E.; Seidl C.; Spriewald B. M.;

  • 作者单位

    Friedrich Alexander Univ Erlangen Nurnberg FAU Dept Internal Med Rheumatol &

    Immunol 3 Univ;

    Friedrich Alexander Univ Erlangen Nurnberg FAU Dept Internal Med Hematol &

    Oncol 5 Univ Klinikum;

    Univ Hosp Essen Inst Transfus Med Essen Germany;

    Univ Hosp Essen Inst Transfus Med Essen Germany;

    Univ Hosp Schleswig Holstein Inst Transfus Med Lubeck Germany;

    Charite Ctr Tumor Med HLA Lab Berlin Germany;

    Gen Hosp Cent Inst Blood Transfus &

    Immunol Innsbruck Austria;

    Ludwig Maximilians Univ Munchen Lab Immunogenet Univ Hosp Grosshadern Munich Germany;

    Katharinenhosp Stuttgart Cent Inst Transfus Med &

    Blood Donat Stuttgart Germany;

    Mahidol Univ Bangkok Histocompatibil &

    Immunogenet Lab Dept Pathol Bangkok Thailand;

    Univ Hosp Basel HLA Diagnost &

    Immunogenet Dept Lab Med Transplantat Immunol &

    Nephrol Dept;

    Univ Basel Transplantat Immunol &

    Nephrol Dept Biomed Basel Switzerland;

    Med Univ Vienna Dept Blood Grp Serol &

    Transfus Med Vienna Austria;

    Univ Hosp Ulm Inst Clin Transfus Med &

    Immunogenet Ulm Germany;

    Hannover Med Sch Inst Transfus Med Hannover Germany;

    Johannes Gutenberg Univ Mainz Transfus Ctr Univ Med Ctr Mainz Germany;

    Inst Transfus Med &

    Immunohaematol German Red Cross Blood Donor Serv Frankfurt Germany;

    Friedrich Alexander Univ Erlangen Nurnberg FAU Dept Internal Med Hematol &

    Oncol 5 Univ Klinikum;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 免疫性疾病;
  • 关键词

    antibodies; graft rejection; graft survival; histocompatibility testing; immunoglobulin isotypes; transplantation;

    机译：抗体;移植物排斥;移植物存活;组织相容性测试;免疫球蛋白同种型;移植;

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