...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJU international >Tunica albuginea acellular matrix graft for penile reconstruction in the rabbit: a model for treating Peyronie's disease.
【24h】

Tunica albuginea acellular matrix graft for penile reconstruction in the rabbit: a model for treating Peyronie's disease.

机译：用于家兔阴茎重建的白膜无细胞基质移植物：治疗佩罗尼氏病的模型。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective To evaluate the use of an acellular matrix graft of the tunica albuginea for functional penile reconstruction in severe cases of Peyronie's disease. Materials and methods In 18 rabbits, an acellular matrix graft of the tunica albuginea was used to cover a 4x8 mm tunical defect, and six animals each were killed 1, 3 and 6 months later; four unoperated animals served as histological controls. Before death an erection was induced by papaverine, with the quality classified on a scale of 0-5, and cavernosography performed. After death the penis was prepared for histological study, and the cell number, collagen and elastic fibre content evaluated in the regenerated matrix, and in control specimens and four unimplanted matrices. Results Of 18 experimental animals, 11 had normal erections before death, four had slight penile deviation and three developed no erection. Failure was caused by severe postoperative haematoma, resulting in scar tissue. There was no graft rejection. Histologically there was no difference between natural and regenerated tunica. The collagen content and cell number were not significantly different in regenerated and control samples. There were significantly fewer elastic fibres in the unimplanted grafts and the 1-month group, but in later samples this difference was no longer evident. Conclusion The homologous acellular matrix graft of the tunica albuginea warrants further evaluation as an alternative treatment in Peyronie's disease, despite some postoperative failures. The advantage of this orthotopic biomaterial is its rapid integration, with no rejection.
机译：目的评估白膜的脱细胞基质移植物在严重的佩罗尼氏病病例中在功能性阴茎重建中的应用。材料和方法在18只兔子中，用白膜无细胞基质移植物覆盖了4x8 mm的管膜缺损，分别在1、3和6个月后杀死了6只动物;每只6只动物被杀死。四只未经手术的动物作为组织学对照。死亡前用罂粟碱引起勃起，质量按0-5级分类，并进行海绵体造影。死亡后，准备好阴茎用于组织学研究，并评估再生基质，对照标本和四个未植入基质中的细胞数量，胶原蛋白和弹性纤维含量。结果在18只实验动物中，有11只在死亡前正常勃起，四只有轻微的阴茎偏斜，三只没有勃起。失败是由严重的术后血肿引起的，导致了瘢痕组织。没有移植排斥反应。从组织学上看，天然和再生的外套之间没有区别。在再生和对照样品中，胶原含量和细胞数量没有显着差异。未植入的移植物和1个月组的弹性纤维明显较少，但在以后的样品中，这种差异不再明显。结论尽管有一些手术失败，但白膜病的同源脱细胞基质移植物仍值得进一步评估作为佩罗尼氏病的替代疗法。这种原位生物材料的优点是其快速整合，没有被拒绝。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号