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首页> 外文期刊>Advances in enzyme regulation >Localization and regulation of muscle fructose- 1,6-bisphosphatase, the key enzyme of glyconeogenesis
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Localization and regulation of muscle fructose- 1,6-bisphosphatase, the key enzyme of glyconeogenesis

机译：肌肉果糖-1,6-双磷酸酶（糖异生的关键酶）的定位和调控

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摘要

D-Fructose-l,6-bisphosphate 1-phosphohydrolase (EC 3.1.3.11) (FBPase) catalyzes the hydrolysis of fructose-1,6-bisphosphate (F-l,6-P_2) to fructose-6-phosphate (F-6-P) and inorganic phosphate in the presence of divalent cations like magnesium, manganese, zinc or cobalt (Benkovic and deMaine, 1982) (Fig. 1). Since its discovery by Gomori in 1943 (Gomori, 1943) the enzyme has been isolated from a number of species, from procariota and eucariota (from yeast, plant, vertebrates and invertebrates). Most researchers have focused their attention on FBPase from vertebrates. The presence of four FBPase isozymes: muscle, liver, brain and intestine in vertebrate tissues has been postulated (Tejwani 1983; Cloix et al., 1997; Mizunuma and Tashima, 1982). However according to Tillmann and Eschrich ( 1998) only liver and muscle genes of FBPase are present in vertebrates. Liver FBPase was recognized as the key enzyme of gluconeogenesis whose activity is hormonally regulated. On the other hand, the physiological role of muscle FBPase as well as its regulation was rather an enigma. The lack of glucose-6-phosphatase activity (EC 3.1.3.9) in muscle cell excluded the possibility of gluconeogenesis. It has been hypothesized that muscle FBPase participates in regulation of glycolysis (Newsholme and Start, 1976).
机译：D-果糖-1,6-二磷酸1-磷酸水解酶（EC 3.1.3.11）（FBPase）催化1,6-双磷酸果糖（Fl，6-P_2）水解为6-磷酸果糖（F-6- P）和无机磷酸盐存在于镁，锰，锌或钴等二价阳离子的存在下（Benkovic and deMaine，1982）（图1）。自1943年由Gomori（Gomori，1943）发现以来，该酶已从procariota和eucariota（酵母，植物，脊椎动物和无脊椎动物）的许多物种中分离出来。大多数研究人员将注意力集中在脊椎动物的FBPase上。假定在脊椎动物组织中存在四种FBPase同工酶：肌肉，肝，脑和肠（Tejwani 1983; Cloix等，1997; Mizunuma和Tashima，1982）。但是根据Tillmann和Eschrich（1998），脊椎动物中仅存在FBPase的肝脏和肌肉基因。肝FBPase被认为是糖异生的关键酶，其活性受激素调节。另一方面，肌肉FBPase的生理作用及其调节是一个谜。肌肉细胞中缺乏葡萄糖-6-磷酸酶活性（EC 3.1.3.9）排除了糖异生的可能性。据推测，肌肉中的FBPase参与了糖酵解的调控（Newsholme and Start，1976）。

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