3-D culture in synthetic extracellular matrices: New tissue models for drug toxicology and cancer drug discovery

Glenn D. Prestwich; Yanchun Liu; Bolan Yu; Xiao Zheng Shu; Anna Scott

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3-D culture in synthetic extracellular matrices: New tissue models for drug toxicology and cancer drug discovery

机译：合成细胞外基质中的3-D培养：用于药物毒理学和癌症药物发现的新组织模型

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Numerous biointeractive hydrogels have been developed for tissue engineering (Lee and Mooney, 2001; Sakiyama-Elbert and Hubbell, 2001), tissue repair, and release of drugs and growth factors (Langer, 2000; Lee et al., 2000) over the past decade. At the Center for Therapeutic Biomaterials (CTB), we have focused on hydrogels based on the extracellular matrix (ECM), a heterogeneous collection of covalent and noncovalent molecular interactions comprised primarily of proteins and glycosaminoglycans (GAGs). In the ECM, covalent interactions connect chondroitin sulfate (CS), heparan sulfate (HS) and other sulfated GAGs to core proteins forming proteoglycans (PGs). Noncovalent interactions include binding of link modules of PGs to hyaluronan (HA), electrostatic associations with ions, hydration of the polysaccharide chains, and triple helix formation to generate collagen fibrils.

机译：过去，已经开发出许多用于组织工程的生物互动水凝胶（Lee和Mooney，2001; Sakiyama-Elbert和Hubbell，2001），组织修复以及药物和生长因子的释放（Langer，2000; Lee等，2000）。十年。在治疗性生物材料中心（CTB），我们专注于基于细胞外基质（ECM）的水凝胶，该凝胶是共价和非共价分子相互作用的异质集合，主要由蛋白质和糖胺聚糖（GAG）组成。在ECM中，共价相互作用将硫酸软骨素（CS），硫酸乙酰肝素（HS）和其他硫酸化GAG连接到形成蛋白聚糖（PGs）的核心蛋白上。非共价相互作用包括PG的连接模块与透明质酸（HA）的结合，与离子的静电缔合，多糖链的水合作用以及三螺旋结构生成以生成胶原纤维。

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《Advances in enzyme regulation》 |2007年第0期|共12页
作者
Glenn D. Prestwich; Yanchun Liu; Bolan Yu; Xiao Zheng Shu; Anna Scott;
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正文语种 eng
中图分类生物化学;
关键词
Extracellular Matrix; drug discovery; Cultural; 细胞外基质;

机译：Extracellular Matrix;drug discovery;Cultural;细胞外基质;

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1. 3-D culture in synthetic extracellular matrices: New tissue models for drug toxicology and cancer drug discovery [J] . Glenn D. Prestwich, Yanchun Liu, Bolan Yu, Advances in enzyme regulation . 2007,第0期

机译：合成细胞外基质中的3-D培养：用于药物毒理学和癌症药物发现的新组织模型
2. Three-Dimensional Tissue Models for Drug Discovery and Toxicology [J] . Francesco Pampaloni, Ernst H. K. Stelzer, Andrea Masotti Recent Patents on Biotechnology . 2009,第2期

机译：药物发现和毒理学的三维组织模型
3. Three-Dimensional Tissue Models for Drug Discovery and Toxicology [J] . Francesco Pampaloni, Ernst H. K. Stelzer, Andrea Masotti Recent Patents on Biotechnology . 2009,第2期

机译：药物发现和毒理学的三维组织模型
4. Disease Specific Cardiac Tissue Models for Drug Discovery and Toxicology [C] . Anurag Mathur, Peter Loskill, SoonGweon Hong, Society for Biomaterials annual meeting and exposition . 2014

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3-D culture in synthetic extracellular matrices: New tissue models for drug toxicology and cancer drug discovery

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