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首页> 外文期刊>Advances in enzyme regulation >Ectopic expression of L-plastin in human tumor cells: Diagnostic and therapeutic implications
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Ectopic expression of L-plastin in human tumor cells: Diagnostic and therapeutic implications

机译：L-plastin在人肿瘤细胞中的异位表达：诊断和治疗意义

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The process of metastasis is complex consisting of a series of sequential steps. Initially, tumor cells detach from the primary tumor, migrate through the surrounding tissue and eventually invade the lymphatic system or blood vessels. As a next step, circulating tumor cells temporarily adhere to endothelial cells and then extravasate by infiltrating the underlying basement membrane. Finally, cells migrate to a suitable location where they proliferate and form metastases (Nicolson, 1988; Stetler-Stevenson et al., 1993; Engers and Gabbert, 2000; Orr et al., 2000). Accordingly, the capacity of tumor cells to form metastatic foci correlates with the ability to proteolytically degrade basement membrane barriers and to adhere to and migrate through extracellular matrix layers (Stetler-Stevenson et al., 1993; Engers and Gabbert, 2000). Modulation of the actin cytoskeleton is critical for tumor cell migration and invasion (Ridley et al., 2003). Therefore, actin-binding proteins which regulate this modulation may be valuable targets to inhibit the invasive properties of tumor cells and, hence, reduce metastasis. Changes in the actin cytoskeleton are accomplished by a variety of actin-binding proteins such as cofilin, a-actinin, filamin, fascin and the plastins (Ridley et al., 2003; Samstag et al., 2003). Interestingly, the hematopoetic isoform of the plastins, L-plastin, is not only expressed by hematopoetic cells, but also by most human cancer cell lines (Lin et al., 1993a; Park et al., 1994). Here, we describe the current knowledge about the expression and function of L-plastin in human cancer cells and its implications for the therapy of cancer.
机译：转移的过程很复杂，包括一系列连续的步骤。最初，肿瘤细胞与原发性肿瘤分离，通过周围组织迁移并最终侵入淋巴系统或血管。下一步，循环中的肿瘤细胞暂时粘附在内皮细胞上，然后通过渗入下面的基底膜而渗出。最后，细胞迁移到合适的位置，在那里增殖并形成转移灶（Nicolson，1988; Stetler-Stevenson等，1993; Engers and Gabbert，2000; Orr等，2000）。因此，肿瘤细胞形成转移灶的能力与蛋白水解降解基底膜屏障以及粘附并迁移通过细胞外基质层的能力有关（Stetler-Stevenson等，1993; Engers和Gabbert，2000）。肌动蛋白细胞骨架的调节对于肿瘤细胞的迁移和侵袭至关重要（Ridley等，2003）。因此，调节这种调节的肌动蛋白结合蛋白可能是抑制肿瘤细胞的侵袭特性并因此减少转移的有价值的靶标。肌动蛋白细胞骨架的变化是通过多种肌动蛋白结合蛋白来完成的，例如cofilin，α-肌动蛋白，丝素蛋白，fascin和质体蛋白（Ridley等，2003; Samstag等，2003）。有趣的是，塑性蛋白的造血同工型L-塑性蛋白不仅由造血细胞表达，而且由大多数人类癌细胞系表达（Lin等，1993a; Park等，1994）。在这里，我们描述了有关L-增塑剂在人类癌细胞中的表达和功能的最新知识及其对癌症治疗的意义。

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