Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis

Bronkhorst Alfred W.; Ketting Rene F.

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Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis

机译：修剪它短：小鼠精子发生期间piRNA成熟需要PNLDC1

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Transposon silencing within the germ line requires the proper processing of piRNA intermediates. However, the enzyme that is required for piRNA 3 end maturation in vertebrates remained enigmatic. Nishimura et al in this issue of EMBO Reports and two independent studies now identified PNLDC1 as the exonuclease that is responsible for piRNA 3 end processing and transposon silencing during mouse spermatogenesis. Together, these studies establish PNLDC1 as the piRNA 3 end trimmer in mouse.

机译：细菌内的转座子沉默需要正确处理piRNA中间体。然而，脊椎动物中PiRNA 3末端成熟所需的酶保持神秘。 Nishimura等人在这个问题的爆发报告和两个独立研究中，现在鉴定了Pnldc1作为对小鼠精子发生期间piRNA 3结束处理和转座子沉默的外切核酸酶。这些研究在一起，将PNLDC1建立为小鼠的PiRNA 3终端修剪器。

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《EMBO reports》 |2018年第3期|共3页
作者
Bronkhorst Alfred W.; Ketting Rene F.;
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Biol Noncoding RNA Inst Mol Biol Mainz Germany;

Biol Noncoding RNA Inst Mol Biol Mainz Germany;

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正文语种 eng
中图分类分子生物学;
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专利

1. Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis [J] . Bronkhorst Alfred W., Ketting Rene F. EMBO reports . 2018,第3期

机译：修剪它短：小鼠精子发生期间piRNA成熟需要PNLDC1
2. PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice [J] . Deqiang Ding, Jiali Liu, Kunzhe Dong, Nature Communications . 2017,第1期

机译：PNLDC1对于小鼠精子发生过程中piRNA 3'末端修剪和转座子沉默至关重要
3. PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development [J] . Nishimura Toru, Nagamori Ippei, Nakatani Tsunetoshi, EMBO reports . 2018,第3期

机译：PNLDC1，小鼠预分子修剪器，是减数分裂和后期后男性生殖细胞发展所必需的
4. Prediction Of Novel Pirna Rat Clusters Based On Mouse Pirna Clusters Using Downstream and Upstream Analysis [C] . Tamer Aldwairi, Federico Hoffmann, Andy D. Perkins International Conference on Bioinformatics and Computational Biology . 2019

机译：基于小鼠piRNA簇的新型PiRNA大鼠簇使用下游分析预测
5. Gametogenesis from fly to mouse: The analysis of the role of spectrosomes and fusomes during Drosophila early oogenesis and the characterization of the miwi gene in mouse spermatogenesis [D] . Deng, Wei 2001

机译：从蝇到小鼠的配子发生：果蝇早期卵子发生过程中光谱体和脂质体的作用分析和小鼠精子发生中miwi基因的表征
6. Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis [O] . Alfred W Bronkhorst, René F Ketting 2018

机译：简而言之：小鼠精子发生过程中piRNA成熟需要PNLDC1
7. piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling [O] . Huang Huiyan, Gao Qun, Peng Xiaoxue, 2011

机译：piRNA相关的生殖细胞成核和精子形成需要MitoPLD多发性线粒体-表面脂质信号转导

Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis

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