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首页> 外文期刊>Advances in enzyme regulation >Phosphatidylinositol transfer protein function in the yeast Saccharomyces cerevisiae.
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Phosphatidylinositol transfer protein function in the yeast Saccharomyces cerevisiae.

机译：磷脂酰肌醇转移蛋白在酿酒酵母中的功能。

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PITPs regulate the interface between lipid metabolism and cellular functions, but the fundamental nature of this regulation is not understood. Yeast and mouse studies demonstrate strict coupling of individual PITPs to specific cellular activities, but the invisibility of these specificities in in vitro models for PITP activity is remarkable. In our opinion, delineation of PITP functions requires the continued application of genetic approaches such as those summarized here. Future studies dedicated to enhancing our understanding of the mechanisms of action of Sec14p-like and metazoan PITPs are worthy goals for three reasons. First, it is becoming abundantly clear that PITPs act at important biological interfaces that involve lipid and protein trafficking, phospholipid biosynthesis and polarized membrane growth. Because these interfaces are critical not only to cellular functions, but also to developmental processes, the function of PITPs in development of multicellular organisms is a particularly attractive area of research that remains essentially untapped. Second, the yeast studies indicate functional linkages between Sec14p-like PITPs and members of ubiquitous but entirely uncharacterized eukaryotic proteins such as OSBP family members. Finally, the link of PITPs to disease is already clear since PITP deficiencies lie at the foundation of novel mechanisms of neurodegenerative, glucose homeostatic and gastrointestinal disorders in mammals. Given that the contribution of Sec14p-like proteins to the PITP complement of mammalian cells is completely uninvestigated, and that the mammalian genome encodes many proteins of this class, we anticipate such advances will directly and positively impact our understanding of the molecular basis of such diseases.
机译：PITP调节脂质代谢和细胞功能之间的界面，但这种调节的基本性质尚不清楚。酵母和小鼠研究表明单个PITP与特定的细胞活性严格偶联，但是在PITP活性的体外模型中这些特异性的隐性是显着的。我们认为，对PITP功能的描述要求继续应用遗传方法，例如此处总结的方法。出于以下三个原因，未来旨在加强我们对Sec14p样和后生PITP的作用机制的理解的研究是值得的目标。首先，非常清楚的是，PITP在重要的生物界面上起作用，这些界面涉及脂质和蛋白质的运输，磷脂的生物合成和极化膜的生长。因为这些接口不仅对细胞功能至关重要，而且对发育过程也很重要，所以PITP在多细胞生物发展中的功能是一个特别吸引人的研究领域，至今仍未开发。其次，酵母研究表明Sec14p样PITP与普遍存在但完全未表征的真核蛋白（例如OSBP家族成员）之间存在功能联系。最后，由于PITP的缺乏是哺乳动物神经退行性，葡萄糖稳态和胃肠道疾病新机制的基础，因此PITP与疾病的联系已经很清楚。鉴于Sec14p样蛋白对哺乳动物细胞PITP补体的贡献尚待研究，并且哺乳动物基因组编码许多此类蛋白，我们预计这些进展将直接并积极地影响我们对此类疾病的分子基础的理解。 。

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