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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >Tumor blood vessels, a difficult hurdle for infiltrating leukocytes
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Tumor blood vessels, a difficult hurdle for infiltrating leukocytes

机译：肿瘤血管，是浸润白细胞的难关

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摘要

In spite of a gradual improvement of its therapy, cancer is still a deadly disease for millions of patients. Immunotherapy is one of promising treatment strategies, but several mechanisms counteract the development of a proper anti-tumor immune response and the formation of an effective inflammatory infiltrate. One of the difficult hurdles is the hampered recruitment of leukocytes from the blood into the tumor site. It has been demonstrated that tumor cells evolved mechanisms to escape immunity, based on down regulation of endothelial adhesion molecules. This paper reviews the endothelial cell adhesion molecules that mediate leukocyte recruitment and the regulation of them during tumor development. In addition, an overview will be given of the translational development and clinical application of the specific composition of adhesion molecules on tumor endothelium, in diagnosis and therapy. (c) 2007 Elsevier B.V. All rights reserved.
机译：尽管其疗法逐渐得到改善，癌症仍然是数百万患者的致命疾病。免疫疗法是一种有前途的治疗策略，但是有几种机制可以抵消适当的抗肿瘤免疫反应的发展以及有效炎性浸润的形成。困难的障碍之一是白细胞从血液进入肿瘤部位的受阻。已经证实，肿瘤细胞基于内皮粘附分子的下调进化出逃避免疫的机制。本文综述了介导白细胞募集的内皮细胞粘附分子及其在肿瘤发展过程中的调控。另外，将概述在诊断和治疗中肿瘤内皮上粘附分子的特定组成的翻译发展和临床应用。 （c）2007 Elsevier B.V.保留所有权利。

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