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首页> 外文期刊>European journal of cancer prevention: The official journal of the European Cancer Prevention Organisation (ECP) >Search for genetic factor association with cancer-free prostate-specific antigen level elevation on the basis of a genome-wide association study in the Korean population
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Search for genetic factor association with cancer-free prostate-specific antigen level elevation on the basis of a genome-wide association study in the Korean population

机译：在韩国人群的基因组协会研究的基础上寻找与无癌症前列腺特异性抗原水平升高的遗传因子关联

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摘要

We investigated the genetic markers associated with elevated serum prostate-specific antigen (sPSA) levels to improve the predictive power of sPSA in screening for prostate cancer. A genome-wide association study was carried out among 4124 healthy Korean male adults using the Affymetrix Axiom Customized Biobank Genotyping Arrays for sPSA levels. A subgroup analysis for increased sPSA levels who underwent a prostate biopsy (n=64) was also carried out. We detected 11 single nucleotide polymorphisms (SNPs) near the Solute carrier family 45member 3, AGAP7P, MSMB, LOC101929917, and KLK3 genes associated with sPSA levels. The top SNP associated with the log of the sPSA levels was rs72434280 in the Solute carrier family 45 member 3 gene (P value, discovery set=2.98x10(-20), replication set=7.31x10(-10)). A case-control study utilizing available biopsy reports (49 patients with normal biopsies vs. 15 patients with biopsies indicating cancer) for the sPSA more than 3ng/ml group was carried out for the respective SNPs after adjusting for age. Only the SNPs near the KLK3 gene were associated with prostate cancer. In the model of the predictive elevation of sPSA level, adding the genetic risk score [area under the curve (AUC)=0.697] to age and BMI (AUC=0.602) significantly improved the results of the AUC (P0.0001). We found seven SNPs associated with elevated prostate-specific antigen levels in healthy Korean men. Four SNPs were a novel marker in the Korean population. In men with increased prostate-specific antigen levels, genotyping SNP related to cancer-free elevation of sPSA level could be informative to decide the indication of prostate biopsy.
机译：我们研究了与升高的血清前列腺特异性抗原（SPSA）水平相关的遗传标志物，以改善SPSA在筛选前列腺癌中的预测力。在4124个健康的韩国男性成人中进行了基因组 - 范围的协会研究，用于SPSA水平的Affymetrix Axiom定制Biobank基因分型阵列。还进行了接受前列腺活检（n = 64）的增加SPSA水平的亚组分析。我们在溶质载体家族450memer 3，AgAP7P，MSMB，Loc11929919299192991917和与SPSA水平相关的KLK3基因中检测到11个单核苷酸多态性（SNP）。与SPSA级别的日志相关联的顶部SNP在溶质载体系列45成员3基因中为RS72434280（P值，发现SET = 2.98x10（-20），复制集= 7.31x10（-10））。在调整年龄调整后，对SPSA具有超过3ng / mL组的SPSA的患者的案检报告（49例患有正常的活检患者的患者，表明癌症的癌组织患者的49名患者）进行了案例对照研究。只有KLK3基因附近的SNP与前列腺癌有关。在SPSA水平的预测升高的模型中，将遗传风险评分[曲线下（AUC）= 0.697]添加到年龄和BMI（AUC = 0.602）显着改善了AUC的结果（P <0.0001）。我们发现七个与健康韩国男性的前列腺特异性抗原水平相关的七个SNP。四个SNP是韩国人口中的一种新型标记。在具有增加的前列腺特异性抗原水平增加的男性中，与SPSA水平的无抗癌升高有关的基因分型SNP可以是暗示前列腺活组织检查的指示。

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